Evidence map›Paper›PMID 31027850›Full record

ArticleAmerican journal of otolaryngology

Predicting transient hypocalcemia in patients with unplanned parathyroidectomy after thyroidectomy.

Ramez Philips, Phillip Nulty, Nolan Seim, Yubo Tan, Guy Brock, Garth Essig

Open access · greenAbstract read
In one paragraph

Article in American journal of otolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Factors affecting the rates of incidental parathyroidectomy during thyroidectomy.Annals of the Royal College of Surgeons of England · 2024
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ramez PhilipsThe Ohio State University College of Medicine, Columbus, OH 43210, USA. Electronic address: ramez.philips@jefferson.edu.
Phillip NultyThe Ohio State University College of Medicine, Columbus, OH 43210, USA.
Nolan SeimDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center and James Cancer Hospital, Columbus, OH 43210, USA.
Yubo TanDepartment of Biomedical Informatics Center for Biostatistics at the Ohio State University College of Medicine, Columbus, OH 43210, USA.
Guy BrockDepartment of Biomedical Informatics Center for Biostatistics at the Ohio State University College of Medicine, Columbus, OH 43210, USA.
Garth EssigDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center and James Cancer Hospital, Columbus, OH 43210, USA.
The Ohio State University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USThe Ohio State University Wexner Medical Center · US

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
NCATS NIH HHS UL1 TR002733
6 · The paper itself

Abstract

objectiveTo assess the utility of rapid parathyroid hormone (PTH) values in predicting transient post-operative hypocalcemia in patients with unplanned parathyroidectomy during total or completion thyroidectomy.

methodsAll patients who underwent total or completion thyroidectomy between January 2010 and January 2015 were reviewed. Incidences of post-operative hypocalcemia were compared in patients with and without unplanned parathyroidectomy. Unplanned parathyroidectomy was defined as intra-operative incidental or intentional parathyroidectomy. Logistic regression assessed for predictors of hypocalcemia and optimum amount of calcium supplementation.

resultsThirty-eight (13.6%) patients had evidence of incidental parathyroidectomy and 39/280 (13.9%) patients had parathyroid autotransplantation intra-operatively. Central neck dissection and malignancy were identified as risk factors for unplanned parathyroidectomy (p = 0.001, p = 0.060). Patients with unplanned parathyroidectomy were more likely to have hypocalcemia (p = 0.002) and hypoparathyroidism (p < 0.0005). PTH value was the only significant predictor of hypocalcemia in these patients. In patients with a post-operative PTH of ≤15, initial calcium supplementation ≥ 1000 mg decreased the risk of hypocalcemia (p < 0.05).

conclusionPost-operative PTH value predicts hypocalcemia in patients undergoing total and completion thyroidectomy with unplanned parathyroidectomy. In patients with a post-operative PTH < 15, initial calcium supplementation with ≥1000 mg of elemental calcium is recommended.

Indexed as

ParathyroidectomyThyroidectomyAdultBiomarkersCalciumFemaleHumansHypocalcemiaIncidenceMaleMiddle AgedParathyroid HormonePostoperative ComplicationsPredictive Value of TestsRisk FactorsBiomarkersCalciumParathyroid HormoneCalcium supplementationHypocalcemiaHypoparathyroidismIncidental parathyroidectomyParathyroid autotransplantationParathyroid hormone

Identifiers

PMID31027850
PMCPMC9017535
OpenAlexW2938760999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.