Evidence map›Paper›PMID 31027519›Full record

ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2019

Effectiveness of Various Floor Contamination Control Methods in Reducing Environmental Organic Load and Maintaining Colony Health in Rodent Facilities.

Jenny M Estes, Yumiko O Hayes, Zachary T Freeman, Craig A Fletcher, Victoria K Baxter

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Comparison of Floor Cleaning and Disinfection Processes in a Research Animal Facility.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jenny M EstesDivision of Comparative Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Yumiko O HayesDivision of Comparative Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Zachary T FreemanDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Craig A FletcherDivision of Comparative Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Victoria K BaxterDivision of Comparative Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;, Email: vkbaxter@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Pathogenesis of and host response to chikungunya virus infection of the central nervous systemK01OD026529 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAXTER, VICTORIA K · 2018 to 2022
$631k
NIH HHS K01 OD026529
6 · The paper itself

Abstract

Floor contamination control practices in rodent housing facilities commonly include disposable shoe covers despite the lack of evidence for their usefulness in bioexclusion. Contamination control flooring mats are advertised as an economical and environmentally-responsible alternative to shoe covers, yet little is published regarding their efficacy in preventing the transfer of organic material and the introduction of infectious agents into facilities. We evaluated 4 floor contamination control strategies-shoe covers (ShCv), contamination control flooring (CCF), using both products concurrently (ShCv+CCF) compared with using neither-in preventing bacterial transfer and reducing organic load on facility floors and maintaining murine colony health status. According to PCR assay and culture analysis, ShCv provided the greatest reduction in bacte- rial numbers. Either ShCv, CCF, or ShCv+CCF significantly decreased ATP levels within the facility compared with those at facility entrances, with ShCv+CCF yielding the greatest reduction; however, even when neither ShCv nor CCF was used, intrafacility floor ATP levels were about half those at entrances. According to PCR analyses, no murine parasitic, viral, and bacterial pathogens excluded at the institution were detected in any floor, exhaust air dust, or sentinel samples at any time or location, regardless of the floor contamination control method in use. These findings show that floor contamination control methods help to reduce the organic load in rodent IVC facilities but do not enhance protection from environmental contamination due to murine pathogens.

Indexed as

Animal HusbandryEnvironmental MicrobiologyFloors and FloorcoveringsLaboratory Animal ScienceProtective ClothingAnimalsEnvironmental MonitoringHumansMiceRodent Diseases

Identifiers

PMID31027519
PMCPMC6526484
OpenAlexW2942232711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.