Evidence map›Paper›PMID 31027504›Full record

ArticleBMC neuroscience2019

Effect of photobiomodulation therapy on neuronal injuries by ouabain: the regulation of Na, K-ATPase; Src; and mitogen-activated protein kinase signaling pathway.

Yun-Hee Rhee, Jeong Hwan Moon, Jae Yun Jung, Connie Oh, Jin-Chul Ahn, Phil-Sang Chung

Open access · goldAbstract read
In one paragraph

Article in BMC neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  8. Transcranial photobiomodulation ameliorates midbrain and striatum neurochemical impairments and behavioral deficits in reserpine-induced parkinsonism in rats.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yun-Hee RheeBeckman Laser Institute Korea, Dankook University, Cheonan, 31116, Republic of Korea.ORCID 0000-0001-7622-5052
Jeong Hwan MoonBeckman Laser Institute Korea, Dankook University, Cheonan, 31116, Republic of Korea.
Jae Yun JungBeckman Laser Institute Korea, Dankook University, Cheonan, 31116, Republic of Korea.
Connie OhBeckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd., Irvine, CA, 92612, USA.
Jin-Chul AhnBeckman Laser Institute Korea, Dankook University, Cheonan, 31116, Republic of Korea.
Phil-Sang ChungBeckman Laser Institute Korea, Dankook University, Cheonan, 31116, Republic of Korea. pschung@dankook.ac.kr.ORCID 0000-0003-4591-2276
Dankook University Hospital · KRDankook University · KRUniversity of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo determine whether photobiomodulation (PBM) rescued the disruption of Na

resultsHCN-2 neuronal cells treated with ouabain showed loss of cell polarity, disrupted cell morphology, and decreased cell viability, which were improved after PBM treatment. We found that ouabain-induced Na, K-ATPase inhibition promoted activation of downstream signaling through Src, Ras, and mitogen-activated protein kinase (MAPK), which were suppressed after PBM treatment. This provided evidence of Na, K-ATPase α-subunit inactivation and intracellular Ca

conclusionsThis study demonstrated that Na

Indexed as

CalciumCells, CulturedCell SurvivalHumansLow-Level Light TherapyMembrane Potential, MitochondrialMitogen-Activated Protein KinasesNeuronsOuabainras ProteinsSignal TransductionSodium-Potassium-Exchanging ATPasesrc-Family KinasesCalciumMitogen-Activated Protein KinasesOuabainras ProteinsSodium-Potassium-Exchanging ATPasesrc-Family KinasesCortical neuronMitochondria membrane potentialNa, K-ATPasePhotobiomodulation

Identifiers

PMID31027504
PMCPMC6486688
OpenAlexW2947625555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.