Evidence map›Paper›PMID 31027353›Full record

ArticlePharmaceutics2019

Re-Epithelialization Appraisal of Skin Wound in a Porcine Model Using a Salmon-Gelatin Based Biomaterial as Wound Dressing.

Cristian A Acevedo, Elizabeth Sánchez, Nicole Orellana, Patricio Morales, Yusser Olguín, Donald I Brown, Javier Enrione

Abstract read
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Therapeutic Management of Malignant Wounds: An Update.Current treatment options in oncology · 2024
    Review
  5. Porous biomaterial scaffolds for skeletal muscle tissue engineering.Frontiers in bioengineering and biotechnology · 2023
    Review
  6. Review
  7. Article
  8. Article
  9. A New Edible Film to Produce In Vitro Meat.Foods (Basel, Switzerland) · 2020
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cristian A AcevedoCentro de Biotecnología, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso 2340000, Chile. cristian.acevedo@usm.cl.
Elizabeth SánchezCentro de Biotecnología, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso 2340000, Chile. elizabeth.sanchez@usm.cl.
Nicole OrellanaCentro de Biotecnología, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso 2340000, Chile. nicole.orellana@usm.cl.
Patricio MoralesCentro de Biotecnología, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso 2340000, Chile. patriciovet@hotmail.com.
Yusser OlguínCentro de Biotecnología, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso 2340000, Chile. yusser77@gmail.com.
Donald I BrownInstituto de Biología, Universidad de Valparaíso, Avenida Gran Bretaña 1111, Valparaíso 2340000, Chile. donald.brown@uv.cl.
Javier EnrioneBiopolymer Research and Engineering Lab, Facultad de Medicina, Universidad de los Andes, Monseñor Álvaro del Portillo 12455, Las Condes, Santiago 7550000, Chile. jenrione@uandes.cl.ORCID 0000-0002-3916-6775

Funding

PMI Grant UAN1303, Conicyt Basal Centre CCTVaL FB0821 and Fondecyt Grant 1171553. UAN1303, FB0821, 1171553
6 · The paper itself

Abstract

The design of new functional materials for skin tissue engineering is an area of constant research. In this work, a novel wound-dressing biomaterial with a porous structure, previously formulated using salmon-gelatin as main component (called salmon-gelatin biomaterial (SGB)), was tested in vivo using pigs as skin wound models. Four weeks after cutaneous excision and implantation in the animals, the healing process did not show apparent symptoms of inflammation or infection. Interestingly, the temporal evolution of wound size from 100% to around 10% would indicate a faster recovery when SGB was compared against a commercial control. Histological analysis established that wounds treated with SGB presented similar healing and epithelialization profiles with respect to the commercial control. Moreover, vascularized granulation tissue and epithelialization stages were clearly identified, indicating a proliferation phase. These results showed that SGB formulation allows cell viability to be maintained. The latter foresees the development of therapeutic alternatives for skin repair based on SGB fabricated using low cost production protocols.

Indexed as

in vivo trialporcine modelsalmon-gelatin biomaterialwound healing

Identifiers

PMID31027353
PMCPMC6571591

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.