ArticleMaterials (Basel, Switzerland)2019
Cell-Free Demineralized Bone Matrix for Mesenchymal Stem Cells Survival and Colonization.
Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Full-Thickness Regeneration of the Hard Palate Using Bioengineered Mucoperiosteal Scaffolds in a Porcine Model.Biomimetics (Basel, Switzerland) · 2026Article
- Moldable Alginate/Hydroxyapatite Hydrogel Loaded with Metformin Enhanced Regeneration of the Rabbit Mandibular Defects.Journal of maxillofacial and oral surgery · 2024Article
- Use of allograft bone matrix in clinical orthopedics.Regenerative medicine · 2024Review
- Osteochondral regenerative engineering: challenges, state-of-the-art and translational perspectives.Regenerative biomaterials · 2023Review
- Development of photoreactive demineralized bone matrix 3D printing colloidal inks for bone tissue engineering.Regenerative biomaterials · 2023Article
- Construction of three-dimensional, homogeneous regenerative cartilage tissue based on the ECG-DBM complex.Frontiers in bioengineering and biotechnology · 2023Article
- 3D printed gelatin/decellularized bone composite scaffolds for bone tissue engineering: Fabrication, characterization and cytocompatibility study.Materials today. Bio · 2022Article
- Remodeling Effects of the Combination of GGT Scaffolds, Percutaneous Electrical Stimulation, and Acupuncture on Large Bone Defects in Rats.Frontiers in bioengineering and biotechnology · 2022Article
- Engineered mucoperiosteal scaffold for cleft palate regeneration towards the non-immunogenic transplantation.Scientific reports · 2021Article
- A Biomimetic Biphasic Scaffold Consisting of Decellularized Cartilage and Decalcified Bone Matrixes for Osteochondral Defect Repair.Frontiers in cell and developmental biology · 2021Article
- Synergic effects of decellularized bone matrix, hydroxyapatite, and extracellular vesicles on repairing of the rabbit mandibular bone defect model.Journal of translational medicine · 2020Article
- Mineral Distribution Spatially Patterns Bone Marrow Stromal Cell Behavior on Monolithic Bone Scaffolds.Acta biomaterialia · 2020Article
- Development of a decellularized porcine bone matrix for potential applications in bone tissue regeneration.Regenerative medicine · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Decellularized bone matrix is receiving much attention as biological scaffolds and implantable biomaterials for bone tissue regeneration. Here, we evaluated the efficacy of a cell-free demineralized bone matrix on mesenchymal stem cells (MSCs) survival and differentiation in vitro. The seeding of human umbilical cord-derived MSCs (hUC-SCs) on decellularized bone matrices up to 14 days was exploited, assessing their capability of scaffold colonization and evaluating gene expression of bone markers. Light and Scanning Electron Microscopies were used. The obtained cell-free decalcified structures showed elastic moduli attributable to both topology and biochemical composition. Morphological observation evidenced an almost complete colonization of the scaffolds after 14 days of culture. Moreover, in hUC-SCs cultured on decalcified scaffolds, without the addition of any osteoinductive media, there was an upregulation of Collagen Type I (COL1) and osteonectin (ON) gene expression, especially on day 14. Modifications in the expression of genes engaged in stemness were also detected. In conclusion, the proposed decellularized bone matrix can induce the in vitro hUC-SCs differentiation and has the potential to be tested for in in vivo tissue regeneration.
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