ArticleGenes2019
Novel Y Chromosome Retrocopies in Canids Revealed through a Genome-Wide Association Study for Sex.
Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Canine reference genome accuracy impacts variant calling: Lessons learned from investigating embryonic lethal variants.Animal genetics · 2022Article
- De-novo and genome-wide meta-analyses identify a risk haplotype for congenital sensorineural deafness in Dalmatian dogs.Scientific reports · 2022Article
- Article
- Recent, full-length gene retrocopies are common in canids.Genome research · 2022Article
- Genomic and Transcriptomic Characterization of Atypical Recurrent Flank Alopecia in the Cesky Fousek.Genes · 2022Article
- Amplified Fragments of an Autosome-Borne Gene Constitute a Significant Component of the W Sex Chromosome ofGenes · 2021Article
- Evaluating human autosomal loci for sexually antagonistic viability selection in two large biobanks.Genetics · 2021Article
- Sequence Transpositions Restore Genes on the Highly Degenerated W Chromosomes of Songbirds.Genes · 2020Article
- The search for sexually antagonistic genes: Practical insights from studies of local adaptation and statistical genomics.Evolution letters · 2020Article
- MultipleGenes · 2020Article
- Variation in breeding practices and geographic isolation drive subpopulation differentiation, contributing to the loss of genetic diversity within dog breed lineages.Canine medicine and genetics · 2020Article
- A new method to identify fetal sex and trisomy 21 from the amniocentesis of pregnant women.Human cell · 2020Article
- Limits to Genomic Divergence Under Sexually Antagonistic Selection.G3 (Bethesda, Md.) · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lack of an annotated reference sequence for the canine Y chromosome has limited evolutionary studies, as well as our understanding of the role of Y-linked sequences in phenotypes with a sex bias. In genome-wide association studies (GWASs), we observed spurious associations with autosomal SNPs when sex was unbalanced in case-control cohorts and hypothesized that a subset of SNPs mapped to autosomes are in fact sex-linked. Using the Illumina 230K CanineHD array in a GWAS for sex, we identified SNPs that amplify in both sexes but possess significant allele frequency differences between males and females. We found 48 SNPs mapping to 14 regions of eight autosomes and the X chromosome that are Y-linked, appearing heterozygous in males and monomorphic in females. Within these 14 regions are eight genes: three autosomal and five X-linked. We investigated the autosomal genes (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.