ArticleNutrients2019
Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status.
Open access · goldAbstract readMulticenter Study
In one paragraph
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.Redox biology · 2025Pooled it
- The Role of rs713041 Glutathione Peroxidase 4 (International journal of molecular sciences · 2022Pooled it
- Zinc, copper, copper-to-zinc ratio, and other biometals in blood serum and tumor tissue of patients with colorectal cancer.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations.Mutagenesis · 2025Article
- Selenium metabolism heterogeneity in pan-cancer: insights from bulk and single-cell RNA sequencing.Journal of cancer research and clinical oncology · 2023Article
- Metabolism and Anticancer Mechanisms of Selocompounds: Comprehensive Review.Biological trace element research · 2023Review
- Genome-Wide Association Study of Metachronous Colorectal Adenoma Risk among Participants in the Selenium Trial.Nutrition and cancer · 2023Article
- Selenoproteins and the senescence-associated epitranscriptome.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Therapeutic Benefits of Selenium in Hematological Malignancies.International journal of molecular sciences · 2022Review
- Article
- Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis.Cellular and molecular life sciences : CMLS · 2022Article
- Trace Element Selenium Effectively Alleviates Intestinal Diseases.International journal of molecular sciences · 2021Review
- Selenium Deficiency Due to Diet, Pregnancy, Severe Illness, or COVID-19-A Preventable Trigger for Autoimmune Disease.International journal of molecular sciences · 2021Review
- A pan-cancer study of selenoprotein genes as promising targets for cancer therapy.BMC medical genomics · 2021Article
- Bioinformatics Analyses Reveal the Prognostic Value and Biological Roles ofInternational journal of general medicine · 2021Article
- The Interaction between Dietary Selenium Intake and Genetics in Determining Cancer Risk and Outcome.Nutrients · 2020Review
- Article
- Tea polyphenols and their chemopreventive and therapeutic effects on colorectal cancer.World journal of gastroenterology · 2020Review
- Association of Circulating Vitamin D With Colorectal Cancer Depends on Vitamin D-Binding Protein Isoforms: A Pooled, Nested, Case-Control Study.JNCI cancer spectrum · 2020Article
- Epitranscriptomic systems regulate the translation of reactive oxygen species detoxifying and disease linked selenoproteins.Free radical biology & medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors at 20 institutions in 13 countries.
Veronika FedirkoDepartment of Epidemiology, Rollins School of Public Health & Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA. veronika.fedirko@emory.edu.
Mazda JenabSection of Nutrition and Metabolism, International Agency for Research on Cancer, 69372 Lyon, France. jenabm@iarc.fr.
Catherine MéplanSchool of Biomedical Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK. Catherine.Meplan@newcastle.ac.uk.
Jeb S JonesDepartment of Epidemiology, Rollins School of Public Health & Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA. jeb.jones@emory.edu.ORCID 0000-0001-9165-1658
Wanzhe ZhuDepartment of Epidemiology, Rollins School of Public Health & Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA. WZHU4@emory.edu.
Lutz SchomburgInstitute for Experimental Endocrinology, University Medical School, D-13353 Berlin, Germany. lutz.schomburg@charite.de.ORCID 0000-0001-9445-1555
Afshan SiddiqDepartment of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London W2 1PG, UK. afshan.siddiq@genomicsengland.co.uk.
Sandra HybsierInstitute for Experimental Endocrinology, University Medical School, D-13353 Berlin, Germany. sandra.hybsier@charite.de.
Kim OvervadDepartment of Public Health, Section for Epidemiology, Aarhus University, 8000 Aarhus, Denmark. ko@dce.au.dk.
Anne TjønnelandDiet, Genes and Environment Unit, Danish Cancer Society Research Center, DK 2100 Copenhagen, Denmark. annet@cancer.dk.
Hanane OmichessanFaculty of Medicine, CESP, University of Paris-Sud, Faculty of Medicine UVSQ, INSERM, University of Paris-Saclay, 94805 Villejuif, France. HANANE.OMICHESSAN@gustaveroussy.fr.
Vittorio PerducaFaculty of Medicine, CESP, University of Paris-Sud, Faculty of Medicine UVSQ, INSERM, University of Paris-Saclay, 94805 Villejuif, France. vittorio.perduca@gmail.com.ORCID 0000-0003-0339-0473
Marie-Christine Boutron-RuaultFaculty of Medicine, CESP, University of Paris-Sud, Faculty of Medicine UVSQ, INSERM, University of Paris-Saclay, 94805 Villejuif, France. boutron@igr.fr.
Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany. t.kuehn@dkfz-Heidelberg.de.
Verena KatzkeDivision of Cancer Epidemiology, German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany. v.katzke@dkfz-Heidelberg.de.
Krasimira AleksandrovaDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany. Krasimira.Aleksandrova@dife.de.
Antonia TrichopoulouHellenic Health Foundation, 115 27 Athens, Greece. atrichopoulou@hhf-greece.gr.
Anna KarakatsaniHellenic Health Foundation, 115 27 Athens, Greece. a.karakatsani@hhf-greece.gr.
Anastasia KotanidouHellenic Health Foundation, 115 27 Athens, Greece. a.kotanidou@hhf-greece.gr.
Rosario TuminoCancer Registry and Histopathology Department, Civic M.P. Arezzo Hospital, 97100 Ragusa, Italy. rtumino@tin.it.ORCID 0000-0003-2666-414X
Salvatore PanicoDepartment of Clinical Medicine and Surgery, Federico II University, 80138 Naples, Italy. spanico@unina.it.
Giovanna MasalaCancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, 50141 Florence, Italy. g.masala@ispo.toscana.it.
Claudia AgnoliEpidemiology and Prevention Unit, IRCCS Foundation National Cancer Institute, 20133 Milan, Italy. claudia.agnoli@istitutotumori.mi.it.ORCID 0000-0003-4472-1179
Alessio NaccaratiMolecular and Genetic Epidemiology Unit, Italian Institute for Genomic Medicine (IIGM) Torino, 10126 Torino, Italy. alessio.naccarati@hugef-torino.org.
Bas Bueno-de-MesquitaDepartment of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London W2 1PG, UK. bas.bueno.de.mesquita@rivm.nl.
Roel C H VermeulenInstitute of Risk Assessment Sciences, Utrecht University, 3512 JE Utrecht, The Netherlands. R.C.H.Vermeulen@uu.nl.
Elisabete WeiderpassDepartment of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, N-0304 Oslo, Norway. WeiderpassE@iarc.fr.ORCID 0000-0003-2237-0128
Guri SkeieDepartment of Community Medicine, University of Tromsø, The Arctic University of Norway, 9019 Tromsø, Norway. Guri.Skeie@ism.uit.no.ORCID 0000-0003-2476-4251
Therese Haugdahl NøstDepartment of Community Medicine, University of Tromsø, The Arctic University of Norway, 9019 Tromsø, Norway. therese.h.nost@uit.no.
Leila Lujan-BarrosoUnit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Spain. llujan@iconcologia.net.ORCID 0000-0001-6224-1764
J Ramón QuirósEPIC Asturias, Public Health Directorate, 33006 Oviedo, Asturias, Spain. joseramon.quirosgarcia@asturias.org.
José María HuertaDepartment of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, 30008 Murcia, Spain. jmhuerta.carm@gmail.com.ORCID 0000-0002-9637-3869
Miguel Rodríguez-BarrancoCIBER Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain. miguel.rodriguez.barranco.easp@juntadeandalucia.es.ORCID 0000-0002-9972-9779
Aurelio BarricarteCIBER Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain. aurelio.barricarte.gurrea@cfnavarra.es.
Björn GyllingDepartment of Medical Biosciences, Pathology, Umea University, 901 87 Umea, Sweden. bjorn.gylling@umu.se.ORCID 0000-0002-4688-8952
Sophia HarlidDepartment of Radiation Sciences, Oncology, Umea University, 901 87 Umea, Sweden. sophia.harlid@umu.se.ORCID 0000-0001-8540-6891
Kathryn E BradburyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK. kathryn.bradbury@ceu.ox.ac.uk.
Nick WarehamMRC Epidemiology Unit, University of Cambridge, CB2 0QQ Cambridge, UK. nick.wareham@mrc-epid.cam.ac.uk.
Kay-Tee KhawSchool of Clinical Medicine, University of Cambridge, Clinical Gerontology Unit, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. kk101@medschl.cam.ac.uk.
Marc GunterSection of Nutrition and Metabolism, International Agency for Research on Cancer, 69372 Lyon, France. GunterM@iarc.fr.
Neil MurphySection of Nutrition and Metabolism, International Agency for Research on Cancer, 69372 Lyon, France. MurphyN@iarc.fr.
Heinz FreislingSection of Nutrition and Metabolism, International Agency for Research on Cancer, 69372 Lyon, France. FreislingH@iarc.fr.ORCID 0000-0001-8648-4998
Kostas TsilidisDepartment of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London W2 1PG, UK. ktsilidis@gmail.com.
Dagfinn AuneDepartment of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London W2 1PG, UK. d.aune@imperial.ac.uk.
Elio RiboliDepartment of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London W2 1PG, UK. e.riboli@imperial.ac.uk.
John E HeskethSchool of Biomedical Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK. j.hesketh@rgu.ac.uk.
David J HughesCancer Biology and Therapeutics Group, UCD Conway Institute, School of Biomolecular and Biomedical Science, University College Dublin, D04 V1W8 Dublin, Ireland. david.hughes@ucd.ie.ORCID 0000-0003-1668-8770
Centre international de recherche sur le cancer · FREmory University · USUniversité Paris-Sud · FRGerman Cancer Research Center · DEImperial College London · GBNational and Kapodistrian University of Athens · GRNewcastle University · GBUiT The Arctic University of Norway · NOUmeå University · SEUniversity of Cambridge · GBAarhus University · DKAzienda Usl 8 Arezzo · ITDanish Cancer Society · DKFederico II University Hospital · ITGerman Institute of Human Nutrition · DEGobierno del Principado de Asturias · ESHellenic Health Foundation · GRInstitut d'Investigació Biomédica de Bellvitge · ESInstituto de Salud Pública de Navarra · ESInstituto Murciano de Investigación Biosanitaria · ES
Funding
Cancer Research UK 14136Health Research Board HRA_PHS/2013/397 and HRA_PHS/2015/1142Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MC_UU_12015/1Medical Research Council MR/N003284/1World Health Organization 001
Abstract
Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes.
Indexed as
GenotypeAdultAgedCohort StudiesColorectal NeoplasmsFemaleGene Expression RegulationGenetic Predisposition to DiseaseHumansMaleMiddle AgedNutritional StatusPolymorphism, Single NucleotideProspective StudiesSeleniumSelenoproteinsSeleniumSelenoproteinsbiomarkerscolorectal cancer riskcolorectal neoplasmsgenetic epidemiologyprospective cohortseleniumselenium pathwayselenium statusselenoprotein gene variationselenoprotein P
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