Evidence map›Paper›PMID 31027156›Full record

ArticleInternational journal of molecular sciences2019

Extracellular l-arginine Enhances Relaxations Induced by Opening of Calcium-Activated SKCa Channels in Porcine Retinal Arteriole.

Ulf Simonsen, Anna K Winther, Aida Oliván-Viguera, Simon Comerma-Steffensen, Ralf Köhler, Toke Bek

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. A KBiomolecules · 2026
    Article
  2. Pirfenidone Is a Vasodilator: Involvement of KFrontiers in pharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Ulf SimonsenDepartment of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, Wilhelm Meyers Allé 4, DK-8000 Aarhus C, Denmark. us@biomed.au.dk.ORCID 0000-0002-2169-7666
Anna K WintherDepartment of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, Wilhelm Meyers Allé 4, DK-8000 Aarhus C, Denmark. annawinther@chem.au.dk.
Aida Oliván-VigueraBESICoS group, Aragón Institute of Engineering Research, IIS-Aragón, University of Zaragoza, 50009 Zaragoza, Spain. aidaolivanviguera@gmail.com.ORCID 0000-0001-5348-924X
Simon Comerma-SteffensenDepartment of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, Wilhelm Meyers Allé 4, DK-8000 Aarhus C, Denmark. simoncomerma@biomed.au.dk.ORCID 0000-0001-6516-694X
Ralf KöhlerAragón Agency for Research and Development (ARAID) at IACS and IIS Aragón, 50009 Zaragoza, Spain. kohler@araid.es.
Toke BekDepartment of Ophthalmology, Aarhus University Hospital, DK-8000 Aarhus C, Denmark. toke.bek@mail.tele.dk.ORCID 0000-0002-0409-2534
Aarhus University · DKAarhus University Hospital · DKFundacion Agencia Aragonesa para la Investigacion y el Desarrollo · ESUniversidad de Zaragoza · ES

Funding

Novo Nordisk Fonden NNF160C0023284Sundhed og Sygdom, Det Frie Forskningsråd DFF 6110-00622
6 · The paper itself

Abstract

We investigated whether the substrate for nitric oxide (NO) production, extracellular l-arginine, contributes to relaxations induced by activating small (SKCa) conductance Ca

Indexed as

AnimalsArginineArteriolesCationic Amino Acid Transporter 1Extracellular SpaceHumansHuman Umbilical Vein Endothelial CellsIon Channel GatingNitric Oxide Synthase Type IIIPyrazolesPyrimidinesRatsRetinal VesselsSmall-Conductance Calcium-Activated Potassium ChannelsSwineVasodilationArginineCationic Amino Acid Transporter 1cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amineNitric Oxide Synthase Type IIIPyrazolesPyrimidinesSmall-Conductance Calcium-Activated Potassium Channelscalcium-activated potassium channelcationic amino acid transporterNO synthaseporcinerelaxationretinal arterioles

Identifiers

PMID31027156
PMCPMC6515554
OpenAlexW2940848762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.