SynthesisMedicine2019
A meta-analysis of laparoscopic surgery versus conventional open surgery in the treatment of colorectal cancer.
Synthesis in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Impact of the absence of opioid anesthesia on postoperative outcome indicators: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Transvaginal versus transabdominal specimen extraction in minimally invasive surgery: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2024Pooled it
- Barriers and facilitators to implementing laparoscopic surgery in low- and middle-income countries: a systematic review using the consolidated framework for implementation research.Surgical endoscopy · 2026Review
- A modified Delphi consensus on fusion (laparoscopic and robotic) approaches to colorectal surgery in Asia-Pacific.Journal of gastroenterology · 2026Article
- Prognostic value of D3 lymph node dissection and nutritional status in colorectal cancer patients aged 80 years and older.International journal of colorectal disease · 2026Article
- Single-incision laparoscopic surgery with transabdominal postperitoneal approach for synchronous ileocecal and sigmoid cancers: a case report.Frontiers in oncology · 2026Article
- Comprehensive Review of Immunotherapy in Colorectal Cancer: From Mechanisms to Nursing Interventions.ImmunoTargets and therapy · 2026Review
- Postoperative outcomes following prehabilitationWorld journal of gastrointestinal surgery · 2025Article
- Towards safer colorectal surgery worldwide: Outcomes and benchmarks from the ESCP CORREA 2022 audit.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Delayed ambulation in adult patients after major abdominal surgery in Northwest Ethiopia: a multicenter prospective follow up study.Scientific reports · 2025Article
- Transfusion Risk in Open, Laparoscopic, and Robotic-Assisted Surgery: A Propensity Score Matched Case-Control Study across Surgical Disciplines.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025Article
- Factors Associated With Prolonged Operative Times in Laparoscopic Right Hemicolectomy and Its Association With Short-Term Outcomes.Journal of surgical oncology · 2025Article
- Evaluation of Short-Term Effects on Colorectal Surgery Elective Patients after Implementing a Patient Blood Management Program: A Multicenter Retrospective Analysis.Journal of clinical medicine · 2024Article
- Article
- Effect of intraoperative blood loss on postoperative complications and prognosis of patients with colorectal cancer: A meta‑analysis.Biomedical reports · 2024Article
- Risk factors of anastomotic leak in colorectal cancer: a multicentric study in a Latin American country.Ecancermedicalscience · 2024Article
- The use of colonic stents as a bridge to surgery in malignant colonic obstruction - A dual trust experience over 10 years.The Ulster medical journal · 2024Review
- Article
- KeyLoop retractor for global gasless laparoscopy: evaluation of safety and feasibility in a porcine model.Surgical endoscopy · 2023Article
- An Asian Tertiary Centre's Early Experience with Laparoscopic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis.Indian journal of surgical oncology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis meta-analysis aimed to explore the overall effect and safety of anterior laparoscopic surgery versus conventional open surgery for patients with colorectal cancer based on eligible randomized controlled trials (RCTs), especially the difference in the postoperative incidence of deep venous thrombosis (DVT).
methodsPubMed, Cochrane, and Embase were searched based on keywords to identify eligible studies before February 2018. Only RCTs were eligible. We analyzed the main outcomes using the relative risk (RR) or mean difference (MD) along with 95% confidence interval (95% CI).
resultsIn this meta-analysis, we analyzed a total of 24 studies with 4592 patients in the laparoscopic surgery group and 3865 patients in the open surgery group. The results indicated that compared with the open surgery, laparoscopic surgery significantly decreased estimated blood loss (SMD: -1.14, 95%CI: -1.70 to -0.57), hospital stay (SMD: -1.12, 95%CI: -1.76 to -0.47), postoperative mortality (RR: 0.60, 95%CI: 0.41-0.86) and postoperative complication (RR: 0.83, 95%CI: 0.72-0.95). However, the operative time (WMD: 40.46, 95%CI: 35.94-44.9) was statistically higher in the laparoscopic surgery group than the open surgery group, and there was no significant difference in the incidence of DVT between the 2 groups (RR: 0.96, 95%CI: 0.46-2.02).
conclusionLaparoscopic surgery is superior to open surgery for patients with colorectal cancer. But the 2 surgeries showed no significant difference in the incidence of DVT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.