Observational studyMedicine2019
Risk factors for graft failure after penetrating keratoplasty.
Observational study in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidence, causative pathogens, risk factors, geographical variations, and outcomes of post-keratoplasty infectious keratitis over the last 15 years: a systematic review and meta-analysis.International ophthalmology · 2025Pooled it
- Gellan Gum Fluid Gel System for Controlled-Delivery of Cytokine-Licensed MSC-EVs to Enhance Corneal Repair in Limbal Stem Cell Deficiency.Advanced healthcare materials · 2026Article
- Risk factors and survival analysis in high-risk penetrating keratoplasty: a retrospective cohort study in 220 patients.BMC ophthalmology · 2026Article
- Non-Descemet Stripping Automated Endothelial Keratoplasty (nDSAEK) for Late Endothelial Failure After Mushroom Keratoplasty: A Retrospective Analysis of Visual and Anatomical Outcomes.Journal of clinical medicine · 2025Article
- Clinical characteristics and risk factors for readmission after deep anterior lamellar keratoplasty: a nationwide, cross-sectional, multicenter study.BMC ophthalmology · 2025Article
- Classification of Histologically Proven Inflammation in Clinically Inactive Corneal Scars: Implications for Graft Outcomes After Penetrating Keratoplasty.Journal of clinical medicine · 2025Article
- A Pilot Case Series on the Use of a Large Mushroom-Shaped Corneal Graft for the Surgical Management of Post-Penetrating Keratoplasty Ectasia and Endothelial Failure.Journal of clinical medicine · 2025Article
- Deep Anterior Lamellar Keratoplasty Versus Penetrating Keratoplasty in Keratoconus: A Retrospective Study Using Coarsened Exact Matching.Journal of ophthalmic & vision research · 2025Article
- Corneal Artificial Endothelial Layer (EndoArt): Literature Review and Our Experience.Journal of clinical medicine · 2024Review
- Keratoconus.Nature reviews. Disease primers · 2024Article
- Risk Factors for Graft Failure After Penetrating Keratoplasty in Eastern China from 2018 to 2021.Annals of transplantation · 2024Article
- Pseudochamber-Protected Keratoplasty (PPK) with a New Inter-Corneal Surgical Device Implant Technique in High-Risk Cases.Journal of clinical medicine · 2024Article
- A Predictive Model for Graft Failure in Femtosecond Laser-Assisted Penetrating Keratoplasty Among Chinese Patients: A 2-Year Study.Ophthalmology and therapy · 2024Article
- Efficacy of Emergency Penetrating Keratoplasty with Cryopreserved Human Donor Corneas.Ophthalmology and therapy · 2024Article
- Biocompatibility and Transplantation Efficacy of the C-Clear Artificial Cornea in a Rabbit Chemical Burn Model.Bioengineering (Basel, Switzerland) · 2023Article
- Management of keratoconus: an updated review.Frontiers in medicine · 2023Review
- Impact of pandemic COVID-19 lockdown on penetrating keratoplasty patients.Indian journal of ophthalmology · 2023Article
- Penetrating Keratoplasty: Indications and Graft Survival by Geographic Region.Seminars in ophthalmology · 2023Article
- Endothelial failure and rejection in recipients of corneas from the same donor.BMJ open ophthalmology · 2022Article
- An attempt to optimize the outcome of penetrating keratoplasty in congenital aniridia-associated keratopathy (AAK).International ophthalmology · 2021Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of our study was to define principal risk factors for graft failure in patients who underwent penetrating keratoplasty (PK).Retrospective data obtained from a cohort of 895 penetrating keratoplasties performed between 2001 and 2006 were analysed. Recipient related factors, graft characteristics, and surgical technique were assessed in a univariate analysis and with a multivariate proportional hazard model to detect principal risk factors for definitive graft failure.Multivariate analysis showed clear significance for diagnosis and number of previous grafts and border line significance for the oldest donor age group. Patients with keratoconus had the best 10-year survival estimate (95%), followed by endothelial and stromal dystrophies (both 55%), infectious leukomas (49%), trauma (33%) and chemical burns (14%). Primary PK grafts had a survival rate of 81%, second grafts of 33% and third or more grafts of 16%. Overall 10-year survival estimate based on univariate analysis was found to be 65%.In conclusion, we found that primary diagnosis and previous graft failures in the recipient are the most important risk factors of graft failure after a PK.
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