ArticleRedox biology2019
Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2.
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Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
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Who cites it
41 citing papers in PubMed, 51 citations in OpenAlex.
- In search of a mouse model of Spaceflight Associated Neuro-ocular Syndrome using one-carbon genetics.Scientific reports · 2026Article
- CR2-fH, A Targeted Inhibitor of Alternative Complement Pathway Reduces Dry AMD-Like Phenotype in AMD Patient iPSC-derived RPE Cells.Investigative ophthalmology & visual science · 2026Article
- Reactive oxygen species/hypoxia dual-responsive polymers combined with melatonin inhibited PANoptosis of retinal ganglion cells for acute glaucoma treatment.Theranostics · 2026Article
- Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health.Journal of neurochemistry · 2025Review
- New insights into methionine's role in maintaining intestinal stem cell regeneration via autophagy regulation.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- Activation of Sigma 1 Receptor Preserves Visual Function After Optic Nerve Injury.Investigative ophthalmology & visual science · 2025Article
- Dysfunctional one-carbon metabolism identifies vitamins BCell reports. Medicine · 2025Article
- Candidate SNP Markers Significantly Altering the Affinity of the TATA-Binding Protein for the Promoters of Human Genes Associated with Primary Open-Angle Glaucoma.International journal of molecular sciences · 2024Article
- Altered Elastin Turnover, Immune Response, and Age-Related Retinal Thinning in a Transgenic Mouse Model With RPE-Specific HTRA1 Overexpression.Investigative ophthalmology & visual science · 2024Article
- Müller Glial Cells in the Macula: Their Activation and Cell-Cell Interactions in Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2024Review
- Probucol attenuates high glucose-induced Müller cell damage through enhancing the Nrf2/p62 signaling pathway.International ophthalmology · 2023Article
- Targeting Mitochondrial Dysfunction and Oxidative Stress to Prevent the Neurodegeneration of Retinal Ganglion Cells.Antioxidants (Basel, Switzerland) · 2023Review
- GSK840 Alleviates Retinal Neuronal Injury by Inhibiting RIPK3/MLKL-Mediated RGC Necroptosis After Ischemia/Reperfusion.Investigative ophthalmology & visual science · 2023Article
- Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicity.Cell communication and signaling : CCS · 2023Article
- EYE-503: A Novel Retinoic Acid Drug for Treating Retinal Neurodegeneration.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Homocysteine and Glaucoma.International journal of molecular sciences · 2023Review
- The Role of Nrf2/sMAF Signalling in Retina Ageing and Retinal Diseases.Biomedicines · 2023Review
- Sigma 1 receptor activation improves retinal structure and function in the RhoExperimental eye research · 2023Article
- Mitochondrial Quality Control and Metabolic Memory Phenomenon Associated with Continued Progression of Diabetic Retinopathy.International journal of molecular sciences · 2023Article
- Controlling the Impact ofMedicina (Kaunas, Lithuania) · 2023Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Soumya NavneetDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA.
Jing ZhaoJames and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA; Department of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Jing WangDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA.
Barbara MysonaDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA; Department of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Shannon BarwickDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA.
Navneet Ammal KaideryDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA; Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Alan SaulJames and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA; Department of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Ismail Kaddour-DjebbarDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, USA; Charlie Norwood VA Medical Center, One Freedom Way, Augusta, GA, 30904, USA.
Wendy B BollagDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, USA; Charlie Norwood VA Medical Center, One Freedom Way, Augusta, GA, 30904, USA.
Bobby ThomasDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA; Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; Department of Drug Discovery, Medical University of South Carolina, Charleston, SC, USA.
Kathryn E BollingerDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA; Department of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Sylvia B SmithDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA; Department of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address: sbsmith@augusta.edu.
Augusta University · USDiscovery Institute · USCharlie Norwood VA Medical Center · USMedical University of South Carolina · US
Funding
Role of homocysteine in retinal diseaseR01EY012830 · NEI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI SMITH, SYLVIA B. · 2000 to 2016
$4.4MThe Mechanism of Sigma 1 Receptor Mediated Neuroprotection in GlaucomaR01EY027406 · NEI · AUGUSTA UNIVERSITY · PI Kathryn Bollinger · 2018 to 2026
$3.2MRole of Bach-1-Mediated Transcriptional Regulation in NeuroprotectionR01NS101967 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI THOMAS, BOBBY · 2017 to 2021
$1.9MSigma 1 Receptor: a novel therapeutic target for retinal degenerationR01EY028103 · NEI · AUGUSTA UNIVERSITY · PI SMITH, SYLVIA B. · 2017 to 2019
$1.2MNEI NIH HHS R01 EY012830NEI NIH HHS R01 EY027406NEI NIH HHS R01 EY028103NINDS NIH HHS R01 NS101967
Abstract
Hyperhomocysteinemia (Hhcy), or increased levels of the excitatory amino acid homocysteine (Hcy), is implicated in glaucoma, a disease characterized by increased oxidative stress and loss of retinal ganglion cells (RGCs). Whether Hhcy is causative or merely a biomarker for RGC loss in glaucoma is unknown. Here we analyzed the role of NRF2, a master regulator of the antioxidant response, in Hhcy-induced RGC death in vivo and in vitro. By crossing Nrf2
Indexed as
AnimalsBiomarkersCell CountCoculture TechniquesDisease Models, AnimalElectroretinographyEpendymoglial CellsGlycolysisHyperhomocysteinemiaIntraocular PressureMiceMice, KnockoutNF-E2-Related Factor 2RetinaRetinal Ganglion CellsBiomarkersNF-E2-Related Factor 2Cystathionine β-synthaseGanglion cellsGlaucomaHomocysteineHyperhomocysteinemiaMethylene tetrahydrofolate reductaseMouseNRF2Retina
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.