ArticleNeurobiology of aging2019
Quantitative assessment of the intracranial vasculature in an older adult population using iCafe.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- A Proposed Novel Neurovascular Mechanism for Brain Network Dysfunction After Traumatic Injury.Annals of biomedical engineering · 2026Article
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- The impact of cerebral vessels morphological alteration and white matter hyperintensities burden on the one-year risk of ischemic stroke recurrence.BMC medical imaging · 2025Article
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- Automated in-depth cerebral arterial labelling using cerebrovascular vasculature reframing and deep neural networks.Scientific reports · 2023Article
- Association between morphologic features of intracranial distal arteries and brain atrophy indexes in cerebral small vessel disease: a voxel-based morphometry study.Frontiers in neurology · 2023Article
- Modification of cerebrovascular morphologies during different stages of life.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Day to Day Blood Pressure Variability Associated With Cerebral Arterial Dilation and White Matter Hyperintensity.Hypertension (Dallas, Tex. : 1979) · 2022Observational
- Urinary sodium and potassium excretion and cerebrovascular health: a multimodal imaging study.European journal of nutrition · 2021Article
- Graph-Based Deep Learning for Medical Diagnosis and Analysis: Past, Present and Future.Sensors (Basel, Switzerland) · 2021Review
- Arterial elasticity, endothelial function and intracranial vascular health: A multimodal MRI study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Vessel length on SNAP MRA and TOF MRA is a potential imaging biomarker for brain blood flow.Magnetic resonance imaging · 2021Article
- Uncontrolled hypertension associates with subclinical cerebrovascular health globally: a multimodal imaging study.European radiology · 2021Article
- Quantitative Assessment of the Intracranial Vasculature of Infants and Adults Using iCafe (Intracranial Artery Feature Extraction).Frontiers in neurology · 2021Article
- Intracranial vascular feature changes in time of flight MR angiography in patients undergoing carotid revascularization surgery.Magnetic resonance imaging · 2021Article
- A novel algorithm for refining cerebral vascular measurements in infants and adults.Journal of neuroscience methods · 2020Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Comprehensive quantification of intracranial artery features may help us assess and understand variations of blood supply during brain development and aging. We analyzed vasculature features of 163 participants (age 56-85 years, mean of 71) from a community study to investigate if any of the features varied with age. Three-dimensional time-of-flight magnetic resonance angiography images of these participants were processed in IntraCranial artery feature extraction technique (a recently developed technique to obtain quantitative features of arteries) to divide intracranial vasculatures into anatomical segments and generate 8 morphometry and intensity features for each segment. Overall, increase in age was found negatively associated with number of branches and average order of intracranial arteries while positively associated with tortuosity, which remained after adjusting for cardiovascular risk factors. The associations with number of branches and average order were consistently found between 3 main intracranial artery regions, whereas the association with tortuosity appeared to be present only in middle cerebral artery/distal arteries. The combination of time-of-flight magnetic resonance angiography and IntraCranial artery feature extraction technique may provide an effective way to study vascular conditions and changes in the aging brain.
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Registered trials
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