ArticleNeurobiology of aging2019
Body mass trajectories and cortical thickness in middle-aged men: a 42-year longitudinal study starting in young adulthood.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 46 citations in OpenAlex.
- Associations between maternal adiposity during pregnancy and neonatal brain cortical development.NeuroImage · 2026Article
- Association of Long-Term Trajectories in Obesity Indices With Neuroimaging Metrics and Cognition: A Population-Based Study.Diabetes, obesity & metabolism · 2026Article
- Aging and metabolism contribute separately to brain-body health.PLoS biology · 2026Article
- Causal relationship between obesity, leptin, and brain structure and functional connectivity: evidence based on bidirectional and mediation mendelian randomisation analyses.Nutrition & metabolism · 2026Article
- Resting-state brain dynamics are associated with body fat percentage and sympathetic outflow in healthy adults.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Obesity and Cognitive Function: Leptin Role Through Blood-Brain Barrier and Hippocampus.Molecular neurobiology · 2025Review
- Longitudinal relationships between pet ownership and cognitive functioning in later adulthood across pet types and individuals' ages.Scientific reports · 2025Article
- Update on Hypothalamic Inflammation and Gliosis: Expanding Evidence of Relevance Beyond Obesity.Current obesity reports · 2025Review
- The effect of weight loss on brain age in schizophrenia spectrum disorders.PLOS mental health · 2025Article
- Understanding Cognitive Decline in Aging: Mechanisms and Mitigation Strategies - A Narrative Review.Clinical interventions in aging · 2025Review
- Hypothalamic volume is associated with age, sex and cognitive function across lifespan: a comparative analysis of two large population-based cohort studies.EBioMedicine · 2025Article
- Brain network fingerprints of Alzheimer's disease risk factors in mouse models with humanized APOE alleles.Magnetic resonance imaging · 2024Article
- Association of early life cardiovascular risk factors with grey matter structure in young adults in the United Kingdom: the ALSPAC study.EBioMedicine · 2024Article
- APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of Aging.bioRxiv : the preprint server for biology · 2024Article
- Association of midlife body-weight variability and cycles with earlier dementia onset: a nationwide cohort study.Alzheimer's research & therapy · 2024Article
- Childhood maltreatment influences adult brain structure through its effects on immune, metabolic, and psychosocial factors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Temporal Interactions between Maintenance of Cerebral Cortex Thickness and Physical Activity from an Individual Person Micro-Longitudinal Perspective and Implications for Precision Medicine.Journal of personalized medicine · 2024Article
- Sustained improvements in brain health and metabolic markers 24 months following bariatric surgery.Brain communications · 2024Article
- Association between Body Mass Index and Brain Health in Adults: A 16-Year Population-Based Cohort and Mendelian Randomization Study.Health data science · 2024Article
- Independent effects of posttraumatic stress disorder diagnosis and metabolic syndrome status on prefrontal cortical thickness and subcortical gray matter volumes.Dialogues in clinical neuroscience · 2023Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 1 country.
Funding
Abstract
Evidence strongly suggests that being overweight or obese at midlife confers significantly higher risk for Alzheimer's disease and greater brain atrophy later in life. Few studies, however, examine associations between longitudinal changes in adiposity during early adulthood and later brain morphometry. Measures of body mass index (BMI) were collected in 373 men from the Vietnam Era Twin Study of Aging at average ages 20, 40, 56, and 62 years, yielding 2 BMI trajectories. We then examined associations between BMI phenotypes (trajectories, continuous BMI, obese/nonobese), cortical thickness, and white matter measures from structural magnetic resonance imaging at mean age 62 (time 4, range 56-66 years). Those on the obesity trajectory (N = 171) had a thinner cortex compared with the normal/lean trajectory (N = 202) in multiple frontal and temporal lobe bilateral regions of interest: superior, inferior, middle temporal gyri, temporal pole, fusiform gyrus, banks of the superior temporal sulcus, frontal pole, pars triangularis, caudal and rostral middle frontal gyri (all p < 0.05, false discovery rate corrected). Frontal lobe thinness tended to occur mainly in the right hemisphere. Results were similar for obese versus nonobese adults at age 62. There were no significant differences for white matter volume or abnormalities. Taken in the context of other research, these associations between brain structures and excess BMI at midlife suggest potential for increased risk for cognitive decline in later life.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.