Evidence map›Paper›PMID 31026178›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2019

Association of intronic DNA methylation and hydroxymethylation alterations in the epigenetic etiology of dilated cardiomyopathy.

Ali M Tabish, Mohammed Arif, Taejeong Song, Zaher Elbeck, Richard C Becker, Ralph Knöll, Sakthivel Sadayappan

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ali M TabishIntegrated Cardio-Metabolic Centre, Karolinska Institutet , Stockholm , Sweden.
Mohammed ArifHeart, Lung, Vascular Institute, Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati , Cincinnati, Ohio.
Taejeong SongHeart, Lung, Vascular Institute, Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati , Cincinnati, Ohio.
Zaher ElbeckIntegrated Cardio-Metabolic Centre, Karolinska Institutet , Stockholm , Sweden.
Richard C BeckerHeart, Lung, Vascular Institute, Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati , Cincinnati, Ohio.
Ralph KnöllIntegrated Cardio-Metabolic Centre, Karolinska Institutet , Stockholm , Sweden.
Sakthivel SadayappanHeart, Lung, Vascular Institute, Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati , Cincinnati, Ohio.
University of Cincinnati · USIntegrated Cardio Metabolic Centre · SEAstraZeneca (Sweden) · SE

Funding

Fast myosin binding protein-C and cardiac contractility in heart failureR01HL105826 · NHLBI · UNIVERSITY OF CINCINNATI · PI SADAYAPPAN, SAKTHIVEL · 2011 to 2025
$4.5M
Skeletal Myosin-Binding Protein C (MyBP-C): Molecular Structure and FunctionR01AR067279 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG, ROGER W, WARSHAW, DAVID M · 2015 to 2019
$2.3M
Molecular mechanism of hypertrophic cardiomyopathy in populations of South Asian descendantsR01HL130356 · NHLBI · UNIVERSITY OF CINCINNATI · PI SADAYAPPAN, SAKTHIVEL · 2016 to 2019
$1.6M
Myoarchitectural Basis of Heart FailureR56HL139680 · NHLBI · OCEAN STATE RESEARCH INSTITUTE, INC. · PI GILBERT, RICHARD J · 2018 to 2018
$431k
NHLBI NIH HHS R01 HL105826NHLBI NIH HHS R01 HL130356NHLBI NIH HHS R56 HL139680NIAMS NIH HHS R01 AR067279
6 · The paper itself

Abstract

In this study, we investigated the role of DNA methylation [5-methylcytosine (5mC)] and 5-hydroxymethylcytosine (5hmC), epigenetic modifications that regulate gene activity, in dilated cardiomyopathy (DCM). A

Indexed as

DNA MethylationEpigenesis, GeneticIntrons5-MethylcytosineAnimalsCardiomyopathy, DilatedCarrier ProteinsCpG IslandsGene Regulatory NetworksGenetic Predisposition to DiseaseHydroxylationMaleMice, Mutant StrainsMutationMyosin Binding Protein CPhenotype5-hydroxymethylcytosine5-MethylcytosineCarrier ProteinsMyosin Binding Protein Cdilated cardiomyopathyDNA hydroxymethylationDNA methylationepigenetics

Identifiers

PMID31026178
PMCPMC6692731
OpenAlexW2941547009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.