Evidence map›Paper›PMID 31025941›Full record

ArticleeLife2019

Disordered breathing in a mouse model of Dravet syndrome.

Fu-Shan Kuo, Colin M Cleary, Joseph J LoTurco, Xinnian Chen, Daniel K Mulkey

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 70 citations in OpenAlex.

  1. Prime editing of a pathogenicScience translational medicine · 2026
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  10. Review
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  13. Sudden Unexpected Death in Epilepsy: Central Respiratory Chemoreception.International journal of molecular sciences · 2025
    Review
  14. Cause of Death Analysis in a 9½-Year-Old with COVID-19 and Dravet Syndrome.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Seizures Cause Prolonged Impairment of Ventilation, COThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Fu-Shan KuoDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Colin M ClearyDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.ORCID 0000-0003-0305-1324
Joseph J LoTurcoDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Xinnian ChenDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Daniel K MulkeyDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.ORCID 0000-0002-7040-3927
University of Connecticut · US

Funding

Glial chemosensitivity: pH sensing and interactions with neuronal chemoreceptorsR01HL104101 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, OLSEN, MICHELLE L · 2010 to 2024
$5.5M
Role of KCNQ2 Channels in Control of BreathingR01HL137094 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, TZINGOUNIS, ANASTASIOS · 2018 to 2025
$4.1M
Developmental Pathophysiology in Neocortex Caused By Somatic MutationsR01NS104999 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI LOTURCO, JOSEPH J · 2018 to 2022
$1.8M
Role of P2Y2 in the Regulation of Vascular Tone and Control of BreathingF31HL142227 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI CLEARY, COLIN · 2018 to 2020
$119k
NHLBI NIH HHS F31 HL142227NHLBI NIH HHS R01 HL104101NHLBI NIH HHS R01 HL137094NIH HHS F31HL142227NIH HHS HL104101NIH HHS HL137094NIH HHS HL142227NIH HHS NS104999NINDS NIH HHS R01 NS104999
6 · The paper itself

Abstract

Dravet syndrome (DS) is a form of epilepsy with a high incidence of sudden unexpected death in epilepsy (SUDEP). Respiratory failure is a leading cause of SUDEP, and DS patients' frequently exhibit disordered breathing. Despite this, mechanisms underlying respiratory dysfunction in DS are unknown. We found that mice expressing a DS-associated

Indexed as

Action PotentialsAnimalsCarbon DioxideDisease Models, AnimalEpilepsies, MyoclonicHumansMiceMutation, MissenseNAV1.1 Voltage-Gated Sodium ChannelNeuronsRespirationSeizuresSudden Unexpected Death in EpilepsyCarbon DioxideNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mousebrainstemchemoreceptionmouseneuroscienceretrotrapezoid nucleusSCN1a missense mutationSUDEP

Identifiers

PMID31025941
PMCPMC6506208
OpenAlexW2901578486

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.