ArticleeLife2019
Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior.
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In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 97 citations in OpenAlex.
- Mesoscale proximity labeling at chromatin leads to identification of small molecule mechanism of action.Nature communications · 2026Article
- Uncoupling memory impairments from autism-associated behaviors in Chd2 deficient mice.Molecular psychiatry · 2026Article
- Genetic Rescue of Disrupted Synaptic Protein Interaction Network Dynamics Following SYNGAP1 Reactivation.Molecular & cellular proteomics : MCP · 2026Article
- The Synaptic Clock: SynGAP1 as a Molecular Timer of Postsynaptic Density Consolidation.Biomolecules · 2026Review
- Genetic medicines for epilepsy: unlocking new avenues for seizure control.Frontiers in bioengineering and biotechnology · 2026Review
- The Endo-GeneScreen platform identifies drug-like probes that regulate endogenous protein levels within physiological contexts.Nature communications · 2025Article
- Genetic rescue of disrupted synaptic protein interaction network dynamics followingbioRxiv : the preprint server for biology · 2025Article
- AAV delivery of full-length SYNGAP1 rescues epileptic and behavioral phenotypes in a mouse model of SYNGAP1-related disorders.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Exploration of a DDX3X Gene Supplementation Therapy Including Expanded Characterization and Novel Findings of Sleep Disturbances inBiological psychiatry global open science · 2025Article
- CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy forbioRxiv : the preprint server for biology · 2025Article
- Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X.Nature communications · 2025Article
- The MNK-SYNGAP1 axis in specific learning disorder: gene expression pattern and new perspectives.European journal of pediatrics · 2025Article
- Epigenetic modulation rescues neurodevelopmental deficits in Syngap1Aging cell · 2025Article
- Article
- DevelopmentalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Subjective sleep assessment in individuals withJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability.Translational psychiatry · 2024Article
- Behavioural and neurodevelopmental characteristics of SYNGAP1.Journal of neurodevelopmental disorders · 2024Article
- Plural molecular and cellular mechanisms of pore domainbioRxiv : the preprint server for biology · 2024Article
- Hyperexcitability and translational phenotypes in a preclinical mouse model ofResearch square · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Thomas K Creson *Department of Neuroscience, The Scripps Research Institute, Jupiter, United States.
Camilo Rojas *Department of Neuroscience, The Scripps Research Institute, Jupiter, United States.
Ernie HwaunDepartment of Neuroscience, Institute for Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, United States.
Thomas VaissiereDepartment of Neuroscience, The Scripps Research Institute, Jupiter, United States.
Murat KilincDepartment of Neuroscience, The Scripps Research Institute, Jupiter, United States.
Andres Jimenez-GomezJan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, United States.
Jimmy Lloyd HolderJan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, United States.
Jianrong TangJan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, United States.
Laura L ColginDepartment of Neuroscience, Institute for Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, United States.
Courtney A MillerDepartment of Neuroscience, The Scripps Research Institute, Jupiter, United States.
Gavin RumbaughDepartment of Neuroscience, The Scripps Research Institute, Jupiter, United States.ORCID 0000-0001-6360-3894
Scripps Research Institute · USBaylor College of Medicine · USThe University of Texas at Austin · US
Funding
Intersection of causal neurodevelopmental disorder risk genes, cortical circuit function, and cognitive processing required for behavioral adaptionsR01MH096847 · NIMH · UNIVERSITY OF FLORIDA · PI Courtney A Miller, GAVIN R RUMBAUGH · 2012 to 2026
$10.4MRegulation of Memory Formation by the GTPase-activating Protein SynGAPR01NS064079 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RUMBAUGH, GAVIN R · 2009 to 2017
$3.9MStudying the effects and mechanisms of deep brain stimulation in Rett syndrome miceR01NS100738 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Jianrong Tang · 2018 to 2026
$3.3MEvaluation of novel biomarkers of cognition in a model of sporadic developmental brain disorders and their application in efficacy testing of Ras pathway inhibitorsR01MH108408 · NIMH · SCRIPPS FLORIDA · PI RUMBAUGH, GAVIN R · 2015 to 2019
$3.3MSynaptic actin dynamics and the selective vulnerability of drug-associated memoryR01DA034116 · NIDA · SCRIPPS FLORIDA · PI MILLER, COURTNEY A · 2013 to 2018
$2.8MMiRNA-mediated mechanisms of long-term traumatic and non-traumatic memory storageR01MH105400 · NIMH · SCRIPPS FLORIDA · PI MILLER, COURTNEY A · 2015 to 2019
$2.5MTraining in Learning and MemoryT32MH106454 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI PRESTON, ALISON R · 2015 to 2025
$2.1MUnderstanding the roles of slow and fast gamma rhythms in memory processingR01MH102450 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI COLGIN, LAURA L · 2014 to 2018
$2.1MRESCUING MOTOR DEFICITS IN SHANK3 RELEATED DISORDERSK08NS091381 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI HOLDER, JIMMY L · 2015 to 2019
$908kNeurodevelopmental impact of prenatal exposure to prescription pain medicationR21DA036376 · NIDA · SCRIPPS FLORIDA · PI MILLER, COURTNEY A · 2014 to 2015
$473kDeep brain stimulation in Rett syndrome mice: cognitive benefits and their mechanismsR56NS100738 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI TANG, JIANRONG · 2017 to 2017
$338kNIDA NIH HHS DA034116NIDA NIH HHS DA036376NIDA NIH HHS R01 DA034116NIDA NIH HHS R21 DA036376NIDA NIH HHS T32DA01892NIMH NIH HHS MH096847NIMH NIH HHS MH102450NIMH NIH HHS MH105400NIMH NIH HHS MH108408NIMH NIH HHS R01 MH096847NIMH NIH HHS R01 MH102450NIMH NIH HHS R01 MH105400NIMH NIH HHS R01 MH108408NIMH NIH HHS T32 MH106454NINDS NIH HHS K08 NS091381NINDS NIH HHS Mentored Clinical Scientist Research Career Development Award NS091381NINDS NIH HHS NS064079NINDS NIH HHS NS100738NINDS NIH HHS R01 NS064079NINDS NIH HHS R01 NS100738NINDS NIH HHS R56 NS100738
Abstract
It remains unclear to what extent neurodevelopmental disorder (NDD) risk genes retain functions into adulthood and how they may influence disease phenotypes.
Indexed as
BehaviorAction PotentialsAgingAnimalsBehavior, AnimalBrainElectroencephalographyFemaleHumansMaleMemoryMiceMice, Mutant Strainsras GTPase-Activating ProteinsSeizuresSleepras GTPase-Activating ProteinsSYNGAP1 protein, humanSyngap1 protein, mouseautismbiomarkercircuitsepilepsyhumanmousemouse modelneurosciencereversal
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.