Evidence map›Paper›PMID 31025936›Full record

ArticleeLife2019

Nuclear receptor NR4A is required for patterning at the ends of the planarian anterior-posterior axis.

Dayan J Li, Conor L McMann, Peter W Reddien

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. eLife · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Cells · 2023
    Article
  15. Article
  16. Article
  17. Principles of regeneration revealed by the planarian eye.Current opinion in cell biology · 2021
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Dayan J LiWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID 0000-0001-8154-9019
Conor L McMannWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID 0000-0002-2264-4646
Peter W ReddienWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID 0000-0002-5569-333X
Howard Hughes Medical Institute · USBoston University · US

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
Stem cell and regeneration regulatory genes in planariansR01GM080639 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI REDDIEN, PETER · 2008 to 2020
$4.6M
Howard Hughes Medical Institute InvestigatorNIGMS NIH HHS R01 GM080639NIGMS NIH HHS T32 GM007287NIGMS NIH HHS T32 GM007753NIH HHS R01GM080639NIH HHS T32GM007753
6 · The paper itself

Abstract

Positional information is fundamental to animal regeneration and tissue turnover. In planarians, muscle cells express signaling molecules to promote positional identity. At the ends of the anterior-posterior (AP) axis, positional identity is determined by anterior and posterior poles, which are putative organizers. We identified a gene,

Indexed as

Body PatterningGene Expression Regulation, DevelopmentalAnimalsPlatyhelminthsReceptors, Cytoplasmic and NuclearReceptors, Cytoplasmic and NuclearAP axisNR4Aorganizerpatterningplanarianpositional informationregenerationregenerative medicinestem cells

Identifiers

PMID31025936
PMCPMC6534381
OpenAlexW2940861781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.