ArticleMolecular plant pathology2019
Comparative genomics reveal pathogenicity-related loci in Pseudomonas syringae pv. actinidiae biovar 3.
Article in Molecular plant pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 63 citations in OpenAlex.
- A conserved Delftibactin A biosynthetic gene cluster plays an important role in the biocontrol of kiwifruit bacterial canker byMicrobiology spectrum · 2026Article
- A Dual-Receptor System MediatesJournal of agricultural and food chemistry · 2026Article
- Prevalence of copper-resistantFrontiers in microbiology · 2026Article
- Integrated transcriptome and metabolome analysis reveals the molecular mechanism underlying differences in Psa resistance betweenFrontiers in plant science · 2026Article
- Calcium-sensing receptor AcCaS regulates chloroplast immunity in kiwifruit by competitively binding with CaHorticulture research · 2025Article
- Novel insights into the genetic basis and transcriptomic elucidation of virulence attenuation inVirulence · 2025Article
- Efficient genome editing in Pseudomonas syringae pv. actinidiae using the CRISPR/FnCas12a system.Molecular horticulture · 2025Article
- Biocontrol Potential, Plant Growth-Promotion, and Genomic Insights ofMicroorganisms · 2025Article
- RetS-mediated environmental sensing coordinates TetR-dependent regulation of type III secretion system and virulence inApplied and environmental microbiology · 2025Article
- AcNAC10, regulated by AcTGA07, enhances kiwifruit resistance to Pseudomonas syringae pv. actinidiae via inhibiting jasmonic acid pathway.Molecular horticulture · 2025Article
- The flavonoid metabolic pathway genes Ac4CL1, Ac4CL3 and AcHCT1 positively regulate the kiwifruit immune response to Pseudomonas syringae pv. actinidiae.Plant molecular biology · 2025Article
- Individually redundant effectors are collectively required for bacterial pathogen virulence.The ISME journal · 2025Article
- Cross-niche protection of kiwi plant against above-ground canker disease by beneficial rhizosphere Flavobacterium.Communications biology · 2024Article
- Genotype-associated core bacteria enhance host resistance against kiwifruit bacterial canker.Horticulture research · 2024Article
- Comparative genomic analyses provide insight into the pathogenicity of three Pseudomonas syringae pv. actinidiae strains from Anhui Province, China.BMC genomics · 2024Article
- Occurrence ofLife (Basel, Switzerland) · 2024Article
- Natural variation in the hrpL promoter renders the phytopathogen Pseudomonas syringae pv. actinidiae nonpathogenic.Molecular plant pathology · 2023Article
- Large-Scale Transposon Mutagenesis Reveals Type III Secretion Effector HopR1 Is a Major Virulence Factor inPlants (Basel, Switzerland) · 2022Article
- Comparative genomics and genomic diversity of Pseudomonas syringae clade 2b-a in Australia.BMC microbiology · 2022Article
- The OmpR-like Transcription Factor as a Negative Regulator ofInternational journal of molecular sciences · 2022Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial canker of kiwifruit, is a severe global disease caused by Pseudomonas syringae pv. actinidiae (Psa). Here, we found that Psa biovar 3 (Psa3) was the only biovar consisting of three widely distributed clades in the largest Chinese kiwifruit cultivated area. Comparative genomics between the three clades revealed 13 polymorphic genes, each of which had multiple intra-clade variations. For instance, we confirmed that the polymorphic copA gene, which encodes a periplasmic protein CopA that is translocated by the Twin-arginine targeting (Tat) system, was involved in copper tolerance. We also found extensive variation in pathogenicity amongst strains within each genetically monomorphic clade. Accordingly, the pathogenic determinants of Psa3 were identified via a genomic comparison of phenotypically different strains within each clade. A case study of the high- and low-virulence strains in the clade 2 of Psa3 revealed that an hfq variant involved in in vitro growth and virulence, while a conserved locus 930 bp upstream of the hrpR gene in the Type III secretion system (T3SS) cluster was required for full pathogenicity on kiwifruit and elicitation of the hypersensitivity response on non-host Nicotiana benthamiana. The '-930' locus is involved in transcriptional regulation of hrpR/S and modulates T3SS function via the hierarchical 'HrpR/S-HrpL-T3SS/effector' regulatory cascade in Psa. Our results provide insights into the molecular basis underlying the genetic diversification and evolution of pathogenicity in Psa3 since kiwifruit canker emerged in China in the 1980s.
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