Evidence map›Paper›PMID 31025560›Full record

ArticleJournal of psychiatry & neuroscience : JPN2019

Adult patients with ADHD differ from healthy controls in implicit, but not explicit, emotion regulation

Lukas Materna, Christian Dirk Wiesner, Anna Shushakova, Julia Trieloff, Nathalia Weber, Alva Engell, Ricarda I. Schubotz, Jochen Bauer, Anya Pedersen, Patricia Ohrmann

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04497363 (Open Label Study for the Use of Transcranial Ultrasound Treatment of Attention Deficit Hyperactive Disorder), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04497363 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Open Label Study for the Use of Transcranial Ultrasound Treatment of Attention Deficit Hyperactive Disorder

TypeinterventionalSponsorNeurological Associates of West Los AngelesRan2020 to 2026Enrolled100ConditionsADHDArmsBrainsonix Pulsar 1002
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Trial
  5. Trial
  6. Cognitive reappraisal modulates neural responses to aversive sensory stimulation in autistic youth.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Article
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  10. Review
  11. Attention Circuits Mediate the Connection between Emotional Experience and Expression within the Emotional Circuit.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023
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  20. Emotional dysregulation and stimulant medication in adult ADHD.Journal of psychiatry & neuroscience : JPN
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lukas MaternaFrom the Department of Psychiatry, School of Medicine, University of Münster, Münster, Germany (Materna, Trieloff, Weber, Engell, Ohrmann); Clinical Psychology and Psychotherapy, Department of Psychology, University of Kiel, Kiel, Germany (Wiesner, Shushakova, Pedersen); the Institute for Psychology, University of Münster, Münster, Germany (Schubotz); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Münster, Germany (Bauer).
Christian Dirk WiesnerFrom the Department of Psychiatry, School of Medicine, University of Münster, Münster, Germany (Materna, Trieloff, Weber, Engell, Ohrmann); Clinical Psychology and Psychotherapy, Department of Psychology, University of Kiel, Kiel, Germany (Wiesner, Shushakova, Pedersen); the Institute for Psychology, University of Münster, Münster, Germany (Schubotz); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Münster, Germany (Bauer).
Anna ShushakovaFrom the Department of Psychiatry, School of Medicine, University of Münster, Münster, Germany (Materna, Trieloff, Weber, Engell, Ohrmann); Clinical Psychology and Psychotherapy, Department of Psychology, University of Kiel, Kiel, Germany (Wiesner, Shushakova, Pedersen); the Institute for Psychology, University of Münster, Münster, Germany (Schubotz); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Münster, Germany (Bauer).
Julia TrieloffFrom the Department of Psychiatry, School of Medicine, University of Münster, Münster, Germany (Materna, Trieloff, Weber, Engell, Ohrmann); Clinical Psychology and Psychotherapy, Department of Psychology, University of Kiel, Kiel, Germany (Wiesner, Shushakova, Pedersen); the Institute for Psychology, University of Münster, Münster, Germany (Schubotz); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Münster, Germany (Bauer).
Nathalia WeberFrom the Department of Psychiatry, School of Medicine, University of Münster, Münster, Germany (Materna, Trieloff, Weber, Engell, Ohrmann); Clinical Psychology and Psychotherapy, Department of Psychology, University of Kiel, Kiel, Germany (Wiesner, Shushakova, Pedersen); the Institute for Psychology, University of Münster, Münster, Germany (Schubotz); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Münster, Germany (Bauer).
Alva EngellFrom the Department of Psychiatry, School of Medicine, University of Münster, Münster, Germany (Materna, Trieloff, Weber, Engell, Ohrmann); Clinical Psychology and Psychotherapy, Department of Psychology, University of Kiel, Kiel, Germany (Wiesner, Shushakova, Pedersen); the Institute for Psychology, University of Münster, Münster, Germany (Schubotz); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Münster, Germany (Bauer).
Ricarda I. SchubotzFrom the Department of Psychiatry, School of Medicine, University of Münster, Münster, Germany (Materna, Trieloff, Weber, Engell, Ohrmann); Clinical Psychology and Psychotherapy, Department of Psychology, University of Kiel, Kiel, Germany (Wiesner, Shushakova, Pedersen); the Institute for Psychology, University of Münster, Münster, Germany (Schubotz); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Münster, Germany (Bauer).
Jochen BauerFrom the Department of Psychiatry, School of Medicine, University of Münster, Münster, Germany (Materna, Trieloff, Weber, Engell, Ohrmann); Clinical Psychology and Psychotherapy, Department of Psychology, University of Kiel, Kiel, Germany (Wiesner, Shushakova, Pedersen); the Institute for Psychology, University of Münster, Münster, Germany (Schubotz); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Münster, Germany (Bauer).
Anya PedersenFrom the Department of Psychiatry, School of Medicine, University of Münster, Münster, Germany (Materna, Trieloff, Weber, Engell, Ohrmann); Clinical Psychology and Psychotherapy, Department of Psychology, University of Kiel, Kiel, Germany (Wiesner, Shushakova, Pedersen); the Institute for Psychology, University of Münster, Münster, Germany (Schubotz); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Münster, Germany (Bauer).
Patricia OhrmannFrom the Department of Psychiatry, School of Medicine, University of Münster, Münster, Germany (Materna, Trieloff, Weber, Engell, Ohrmann); Clinical Psychology and Psychotherapy, Department of Psychology, University of Kiel, Kiel, Germany (Wiesner, Shushakova, Pedersen); the Institute for Psychology, University of Münster, Münster, Germany (Schubotz); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Münster, Germany (Bauer).
FH Münster · DEUniversity Hospital Münster · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is increasing evidence that people with attention-deficit/hyperactivity disorder (ADHD) are impaired in emotion regulation, but psychophysiological and functional MRI data on emotion processing in adult patients with ADHD are scarce. We investigated the neural correlates of reappraisal as one of the most efficient emotion-regulation strategies. Methods: We included 30 adult patients with ADHD and 35 healthy controls in our study. We applied a well-established reappraisal paradigm in functional MRI and assessed behavioural emotion-regulation strategies with standardized questionnaires. We hypothesized that patients with ADHD would demonstrate impaired reappraisal related to reduced activations in the frontoparietal cognitive control network. Results: Despite our hypothesis, we found no significant activation differences in the neural reappraisal network between patients with ADHD and controls. As well, both groups revealed similar reappraisal success on the immediate behavioural ratings in the scanner. Interestingly, patients with ADHD revealed significantly increased activations in the dorsal and ventral anterior cingulate cortex (ACC) compared to controls when viewing negative > neutral pictures. These ACC activations were significantly correlated with the prevalence of habitual use of reappraisal in patients with ADHD only. Limitations: Patients withdrew medication only 24 hours before the experiment; we investigated negative, but not positive, emotion processing and regulation. Conclusion: Although emotion dysregulation is regarded as a core symptom of ADHD, explicit reappraisal does not seem to be impaired in adult patients. However, increased activation of the ACC implies stronger implicit emotion regulation induced by negative stimuli. This might be explained by emotional hyperresponsivity in patients with ADHD compared with controls.

Indexed as

Emotional RegulationAdultAttention Deficit Disorder with HyperactivityCase-Control StudiesFemaleFrontal LobeFunctional NeuroimagingGyrus CinguliHumansMagnetic Resonance ImagingMaleNeural PathwaysParietal LobeYoung Adult

Identifiers

PMID31025560
PMCPMC6710085
OpenAlexW2971094160

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.