ArticleMicrobial biotechnology2019
Effective elimination of Staphylococcal contamination from hospital surfaces by a bacteriophage-probiotic sanitation strategy: a monocentric study.
Article in Microbial biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Review
- Large-scale analysis of bacterial genomes reveals thousands of lytic phages.Nature microbiology · 2026Article
- Harnessing probiotics and bacteriophages to fight Salmonella and limit the use of antibiotics in broilers: a study in commercial conditions.Poultry science · 2025Article
- Probiotic-Based Cleaning Solutions: From Research Hypothesis to Infection Control Applications.Biology · 2025Review
- Probiotic-Based Approaches for Sustainable Control of Infectious Risk in Mass Transport: Current Data and Future Perspectives.Microbial biotechnology · 2025Review
- Microbes Saving Lives and Reducing Suffering.Microbial biotechnology · 2025Article
- Tackling transmission of infectious diseases: A probiotic-based system as a remedy for the spread of pathogenic and resistant microbes.Microbial biotechnology · 2024Review
- Biocontrol in built environments to reduce pathogen exposure and infection risk.The ISME journal · 2024Review
- A critical assessment of microbial-based antimicrobial sanitizing of inanimate surfaces in healthcare settings.Frontiers in microbiology · 2024Review
- Bacillus-based probiotic cleansers reduce the formation of dry biofilms on common hospital surfaces.MicrobiologyOpen · 2023Article
- Bacteriophages in Infectious Diseases and Beyond-A Narrative Review.Antibiotics (Basel, Switzerland) · 2023Review
- [Health Technology Assessment of the introduction of the Probiotic Cleaning Hygiene System (PCHS) in the Italian healthcare setting: update].Journal of preventive medicine and hygiene · 2023Article
- Potential Use of a Combined Bacteriophage-Probiotic Sanitation System to Control Microbial Contamination and AMR in Healthcare Settings: A Pre-Post Intervention Study.International journal of molecular sciences · 2023Article
- Shaping the subway microbiome through probiotic-based sanitation during the COVID-19 emergency: a pre-post case-control study.Microbiome · 2023Article
- The Microbiome of the Built Environment: The Nexus for Urban Regeneration for the Cities of Tomorrow.Microorganisms · 2022Article
- Applications of Bacteriophage Cocktails to Reduce Salmonella Contamination in Poultry Farms.Food and environmental virology · 2022Article
- Pathogen Control in the Built Environment: A Probiotic-Based System as a Remedy for the Spread of Antibiotic Resistance.Microorganisms · 2022Article
- Bacteriophage-based decontamination to control environmental colonization byFrontiers in cellular and infection microbiology · 2022Article
- Determination of phage load and administration time in simulated occurrences of antibacterial treatments.Frontiers in medicine · 2022Article
- [Health Technology Assessment of the Probiotic Cleaning Hygiene System (PCHS)].Journal of preventive medicine and hygiene · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent contamination of hospital surfaces and antimicrobial resistance (AMR) is recognized as major causes of healthcare-associated infections (HAI). We recently showed that probiotic-based sanitation (PCHS) can stably decrease surface pathogens and reduce AMR and HAIs. However, PCHS action is slow and non-specific. By contrast, bacteriophages have been proposed as a decontamination method as they can rapidly attack specific targets, but their routine application has never been tested. Here, we analysed the feasibility and effectiveness of phage addition to PCHS sanitation, aiming to obtain a rapid and stable abatement of specific pathogens in the hospital environment. Staphylococcal contamination in the bathrooms of General Medicine wards was analysed, being those areas the most contaminated and Staphylococci the most prevalent bacteria in such settings. Results showed that a daily phage application by nebulization induced a rapid and significant decrease in Staphylococcus spp. load on treated surfaces, up to 97% more than PCHS alone (P < 0.001), suggesting that such a system might be considered as a part of prevention and control strategies, to counteract outbreaks of specific pathogens and prevent associated infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.