Observational studyObesity surgery2019
Changes in Thyroid Replacement Therapy after Bariatric Surgery: Differences between Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy.
Observational study in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Levothyroxine dose requirements, oral bioavailability and gut microbiome enterotype dynamics during the early post-bariatric period: a single-centre, prospective, cohort study.BMC endocrine disorders · 2026Article
- Different impact of sleeve gastrectomy and Roux-en-Y gastric bypass on thyroid function and levothyroxine requirements.Eating and weight disorders : EWD · 2026Observational
- Outcomes of Bariatric Surgery in Hypothyroid Patients Taking Levothyroxine: A Systematic Review and Meta-Analysis.Cureus · 2025Review
- Effect of Laparoscopic Sleeve Gastrectomy on Hypothyroidism in Patients with Morbid Obesity: A one-year follow-up Prospective Cohort Study.Iranian journal of pathology · 2025Article
- Effect of Laparoscopic Sleeve Gastrectomy on Thyroid Function Tests and Levothyroxine Doses in People With Obesity.Cureus · 2024Article
- Long-term Effect of Bariatric Surgery on the Use of Levothyroxine and Thyroid Levels.Obesity surgery · 2022Observational
- Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery.Journal of clinical medicine · 2022Review
- Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss.Journal of clinical medicine · 2021Article
- Hypothyroidism following gastric sleeve surgery resolved by ingesting crushed thyroxine tablets.Proceedings (Baylor University. Medical Center) · 2020Article
- Treatment with Intramuscular Levothyroxine in Refractory Hypothyroidism.European thyroid journal · 2019Article
- Major imbalance of thyroid function after laparoscopic sleeve gastrectomy.BMJ case reports · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLevothyroxine (LT4) requirements can presumably be modified differently after laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG). The present study compared changes in LT4 dose in hypothyroid subjects undergoing LRYGB or LSG 2 years after the procedure. MATERIAL AND
methodsA 2-year follow-up observational study was conducted in a prospective cohort of obese patients who had undergone bariatric surgery and were receiving LT4. Indication for the type of surgical procedure was based on clinical criteria. Repeated measures ANOVA models were used to examine differences within and between groups.
resultsThirty-five consecutive patients were included for analysis: 22 LRYGB and 13 LSG. Total daily LT4 dosage decreased in the LSG group (133.7 ± 50.3 mcg/day at baseline to 104.3 ± 43.3 mcg/day at 2 years; p = 0.047) whereas it remained stable in the LRYGB group (129.5 ± 46.1 mcg/day at baseline to 125.2 ± 55.7 mcg/day at 2 years; p = 1.000). Differences between groups became significant at 24 months. Daily weight-based LT4 dose increased in the LRYGB group (1.11 ± 0.38 mcg/kg day at baseline to 1.57 ± 0.74 mcg/kg day at 2 years; p = 0.005) with no significant changes in the LSG group (1.15 ± 0.35 mcg/kg day at baseline vs 1.11 ± 0.49 mcg/kg day at 2 years; p = 1.000).
conclusionLRYGB and LSG showed different changes in LT4 requirements 2 years after surgery. There was an early decrease in daily total LT4 dose requirements after LSG, which suggests an early preventive reduction to be validated in future studies.
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