Evidence map›Paper›PMID 31025246›Full record

ArticleJournal of nephrology2020

Morphological evaluation of sympathetic renal innervation in patients with autosomal dominant polycystic kidney disease.

Valentina Rovella, Manuel Scimeca, Elena Giannini, Adriana D'Ercole, Erica Giacobbi, Annalisa Noce, Gabriele D'Urso, Alessandro Anselmo, Pierluigi Bove, Giuseppe Santeusanio and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Cardiovascular Manifestations and Management in ADPKD.Kidney international reports · 2023
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Valentina RovellaDivision of Internal Medicine and Nephrology, Policlinico Tor Vergata, viale oxford 81, Rome, 00133, Italy.
Manuel ScimecaAnatomic Pathology, Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy.ORCID http://orcid.org/0000-0003-0585-1309
Elena GianniniAnatomic Pathology, Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy.
Adriana D'ErcoleAnatomic Pathology, Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy.
Erica GiacobbiAnatomic Pathology, Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy.
Annalisa NoceDivision of Internal Medicine and Nephrology, Policlinico Tor Vergata, viale oxford 81, Rome, 00133, Italy.
Gabriele D'UrsoDivision of Internal Medicine and Nephrology, Policlinico Tor Vergata, viale oxford 81, Rome, 00133, Italy.
Alessandro AnselmoTransplantation Surgery, Department of Surgery Policlinico Tor Vergata Foundation, Rome, Italy.
Pierluigi BoveUrology, Department of Surgery, University of Rome "Tor Vergata", Rome, Italy.
Giuseppe SanteusanioAnatomic Pathology, Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy.
Elena BonannoAnatomic Pathology, Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy.
Maurizio CasascoFederazione Medico Sportiva Italiana, Rome, Italy.
Silvestro MaurielloDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy.
Nicola Di DanieleDivision of Internal Medicine and Nephrology, Policlinico Tor Vergata, viale oxford 81, Rome, 00133, Italy.
Alessandro MaurielloAnatomic Pathology, Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy. alessandro.mauriello@uniroma2.it.
Lucia AnemonaAnatomic Pathology, Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy.
University of Rome Tor Vergata · ITPoliclinico Tor Vergata · ITFederazione Medico Sportiva Italiana · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several evidences support the hypothesis that patients affected by autosomal dominant polycystic kidney disease (ASPKD) show a sympathetic renal hyperactivity. Nevertheless, no morphological evidences are available yet. Therefore, the aim of the study was to demonstrate that an increase in sympathetic renal artery innervation was present in the ADPKD patients by using histological methods. In addition, here we correlated the sympathetic renal artery innervation with the evolutionary state of ADPKD (increase in volume of kidney, onset of chronic renal failure and hypertension). To this end, peri-adventitial innervation of renal arteries was studied using morphological methods from 49 patients in total: 29 underwent surgical nephrectomies for ADPKD and 20 non-dialysis patients (CTRL group) undergoing nephrectomy for other diseases. Nerve density (number of nerves per mm

Indexed as

AdultAdventitiaAgedAged, 80 and overCase-Control StudiesFemaleHumansHypertensionMaleMiddle AgedNephrectomyPolycystic Kidney, Autosomal DominantRenal ArterySympathetic Nervous SystemADPKDHistologyRenal denervationSympathetic renal hyperactivity

Identifiers

PMID31025246
OpenAlexW2941132035

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.