Evidence map›Paper›PMID 31025221›Full record

ReviewAnnals of intensive care2019

Ventilation in patients with intra-abdominal hypertension: what every critical care physician needs to know.

Adrian Regli, Paolo Pelosi, Manu L N G Malbrain

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Annals of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07085286 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Prognostic Value of Continuous Intra-abdominal Pressure (CIAP) and Continuous Abdominal Perfusion Pressure (CAPP) Monitoring for Acute Kidney Injury (AKI) Prediuction in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery

Typeobservational_patient_registrySponsorMedical University of LublinRan2026 to 2026Enrolled45ConditionsAKI - Acute Kidney Injury, CABGArmsContinous IAP measurement
NCT07154589 recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of AbClo Fascial Approximation Device in Patients With Open Abdomen on Respiratory Mechanics (AbClo-Resp)

TypeobservationalSponsorUnity Health TorontoRan2025 to 2026Enrolled18ConditionsOpen Abdomen, Mechanical Ventilation
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 144 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Airway pressure reliably predicts intra-abdominal pressure during laparoscopic surgery.Hernia : the journal of hernias and abdominal wall surgery · 2026
    Observational
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  15. In-Hospital Mortality in Mechanically Ventilated Children With Severe Dengue Fever: Explanatory Factors in a Single-Center Retrospective Cohort From Vietnam, 2013-2022.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 4 countries.

Adrian RegliDepartment of Intensive Care, Fiona Stanley Hospital, Murdoch Drive, Murdoch, WA, 6152, Australia.
Paolo PelosiDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
Manu L N G MalbrainIntensive Care Unit, University Hospital Brussels (UZB), Jette, Belgium. manu.malbrain@uzbrussel.be.ORCID http://orcid.org/0000-0002-1816-5255
Ospedale Policlinico San Martino · ITThe University of Western Australia · AUVrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of intra-abdominal hypertension (IAH) is high and still underappreciated by critical care physicians throughout the world. One in four to one in three patients will have IAH on admission, while one out of two will develop IAH within the first week of Intensive Care Unit stay. IAH is associated with high morbidity and mortality. Although considerable progress has been made over the past decades, some important questions remain regarding the optimal ventilation management in patients with IAH. An important first step is to measure intra-abdominal pressure (IAP). If IAH (IAP > 12 mmHg) is present, medical therapies should be initiated to reduce IAP as small reductions in intra-abdominal volume can significantly reduce IAP and airway pressures. Protective lung ventilation with low tidal volumes in patients with respiratory failure and IAH is important. Abdominal-thoracic pressure transmission is around 50%. In patients with IAH, higher positive end-expiratory pressure (PEEP) levels are often required to avoid alveolar collapse but the optimal PEEP in these patients is still unknown. During recruitment manoeuvres, higher opening pressures may be required while closely monitoring oxygenation and the haemodynamic response. During lung-protective ventilation, whilst keeping driving pressures within safe limits, higher plateau pressures than normally considered might be acceptable. Monitoring of the respiratory function and adapting the ventilatory settings during anaesthesia and critical care are of great importance. This review will focus on how to deal with the respiratory derangements in critically ill patients with IAH.

Indexed as

Abdominal compartment syndromeComplianceDriving pressureIntra-abdominal hypertensionIntra-abdominal pressureMechanical ventilationPositive end-expiratory pressureProtective ventilationRecruitmentVentilator-induced lung injury

Identifiers

PMID31025221
PMCPMC6484068
OpenAlexW2944584189

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.