ArticleFrontiers in chemistry2019
The Bioavailability, Biodistribution, and Toxic Effects of Silica-Coated Upconversion Nanoparticles
Article in Frontiers in chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Nanotechnology-based strategies for helminth control: drug delivery, green nanoparticles, mechanisms, and translational barriers.Discover nano · 2026Review
- Surface bioengineering of lanthanide nanoparticles for theranostic applications: From hydrophilic modification to multimodal imaging and therapy.Materials today. Bio · 2026Review
- Revisiting the potential of upconversion nanoparticles in biomedical applications: Advances and emerging perspectives.Materials today. Bio · 2026Review
- Piperazine-Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nanotoxicity of Porous Silica Nanoparticles: Physicochemical Properties and Mechanistic Cellular Endpoints.Nanomaterials (Basel, Switzerland) · 2025Review
- Article
- Engineered upconversion nanoparticles for breast cancer theranostics.Theranostics · 2025Review
- Review
- Construction and Biological Evaluation of Different Nanoshell Thickness Ni@SiOCurrent medicinal chemistry · 2025Article
- Lanthanide ion-doped upconversion nanoparticles for low-energy super-resolution applications.Light, science & applications · 2024Review
- Au@CuS Nanoshells for Surface-Enhanced Raman Scattering Image-Guided Tumor Photothermal Therapy with Accelerated Hepatobiliary Excretion.Pharmaceutics · 2024Article
- Toxicity of Large and Small Surface-Engineered Upconverting Nanoparticles for In Vitro and In Vivo Bioapplications.International journal of molecular sciences · 2024Article
- Review
- Upconversion Nanoparticles Intercalated in Large Polymer Micelles for Tumor Imaging and Chemo/Photothermal Therapy.International journal of molecular sciences · 2023Article
- Upconversion Nanomaterials in Bioimaging and Biosensor Applications and Their Biological Response.Nanomaterials (Basel, Switzerland) · 2022Review
- Upconversion Nanostructures Applied in Theranostic Systems.International journal of molecular sciences · 2022Review
- Lanthanide-Doped Upconversion Luminescent Nanoparticles-Evolving Role in Bioimaging, Biosensing, and Drug Delivery.Materials (Basel, Switzerland) · 2022Review
- Silica Nanoparticle Acute Toxicity on MaleFrontiers in bioengineering and biotechnology · 2022Article
- From Raman to SESORRS: moving deeper into cancer detection and treatment monitoring.Chemical communications (Cambridge, England) · 2021Review
- Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells.Beilstein journal of nanotechnology · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lanthanide-doped upconversion nanoparticles can convert long wavelength excitation radiation to short wavelength emission. They have great potential in biomedical applications, such as bioimaging, biodetection, drug delivery, and theranostics. However, there is little information available on their bioavailability and biological effects after oral administration. In this study, we systematically investigated the bioavailability, biodistribution, and toxicity of silica-coated upconversion nanoparticles administrated by gavage. Our results demonstrate that these nanoparticles can permeate intestinal barrier and enter blood circulation by microstructure observation of Peyer's patch in the intestine. Comparing the bioavailability and the biodistribution of silica-coated upconversion nanoparticles with oral and intravenous administration routes, we found that the bioavailability and biodistribution are particularly dependent on the administration routes. After consecutive gavage for 14 days, the body weight, pathology, Zn and Cu level, serum biochemical analysis, oxidative stress, and inflammatory cytokines were studied to further evaluate the potential toxicity of the silica-coated upconversion nanoparticles. The results suggest that these nanoparticles do not show overt toxicity in mice even at a high dose of 100 mg/kg body weight.
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Registered trials
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