Evidence map›Paper›PMID 31024849›Full record

ArticleFrontiers in oncology2019

A Novel Mechanism of High Dose Radiation Sensitization by Metformin.

Stephen L Brown, Andrew Kolozsvary, Derek M Isrow, Karine Al Feghali, Karen Lapanowski, Kenneth A Jenrow, Jae Ho Kim

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Radiation-induced senescence: therapeutic opportunities.Radiation oncology (London, England) · 2023
    Review
  6. Article
  7. Review
  8. Review
  9. RETRACTED: Metformin and Breast Cancer: Where Are We Now?International journal of molecular sciences · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Stephen L BrownDepartment of Radiation Oncology, Henry Ford Hospital, Detroit, MI, United States.
Andrew KolozsvaryDepartment of Radiation Oncology, Henry Ford Hospital, Detroit, MI, United States.
Derek M IsrowDepartment of Radiation Oncology, Henry Ford Hospital, Detroit, MI, United States.
Karine Al FeghaliDepartment of Radiation Oncology, Henry Ford Hospital, Detroit, MI, United States.
Karen LapanowskiDepartment of Radiation Oncology, Henry Ford Hospital, Detroit, MI, United States.
Kenneth A JenrowDepartment of Radiation Oncology, Henry Ford Hospital, Detroit, MI, United States.
Jae Ho KimDepartment of Radiation Oncology, Henry Ford Hospital, Detroit, MI, United States.
Henry Ford Hospital · US

Funding

MRI Signatures of Response to High-Dose Radiotherapy in Rat Models of Cerebral TumorR01CA218596 · NCI · HENRY FORD HEALTH SYSTEM · PI BROWN, STEPHEN L, EWING, JAMES R · 2018 to 2022
$2.4M
Improving the radiation therapeutic ratio by inhibiting proinflammatory cytokinesR21CA205660 · NCI · HENRY FORD HEALTH SYSTEM · PI KIM, JAE HO · 2017 to 2018
$360k
NCI NIH HHS R01 CA218596NCI NIH HHS R21 CA205660
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cancerglucosemetabolismmetforminradiationtumor blood flow

Identifiers

PMID31024849
PMCPMC6465931
OpenAlexW2940279619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.