ArticleInternational journal of ophthalmology2019
Identification of pathogenic genes of pterygium based on the Gene Expression Omnibus database.
Article in International journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- KRT6A and KRT17 Mark Distinct Stem Cell Populations in the Adult Palpebral Conjunctiva and Meibomian Gland.Cells · 2025Article
- Assessing genetic and environmental components for pterygium: a nationwide study in Taiwan.Scientific reports · 2024Article
- Advances in artificial intelligence applications for ocular surface diseases diagnosis.Frontiers in cell and developmental biology · 2022Review
- A Novel System for Measuring Pterygium's Progress Using Deep Learning.Frontiers in medicine · 2022Article
- Identification of the circRNA-miRNA-mRNA Regulatory Network in Pterygium-Associated Conjunctival Epithelium.BioMed research international · 2022Article
- Transcriptome Analysis of Pterygium and Pinguecula Reveals Evidence of Genomic Instability Associated with Chronic Inflammation.International journal of molecular sciences · 2021Article
- Lack of HPV in pterygium with no evidence of autoinoculation and the role of cytokines in pterygium with dry eye.Scientific reports · 2021Observational
- Comparative Transcriptomic Analysis to Identify the Important Coding and Non-coding RNAs Involved in the Pathogenesis of Pterygium.Frontiers in genetics · 2021Article
- The novel mutation P36R in LRP5L contributes to congenital membranous cataract via inhibition of laminin γ1 and c-MAF.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- The placental transcriptome of the first-trimester placenta is affected by in vitro fertilization and embryo transfer.Reproductive biology and endocrinology : RB&E · 2019Article
- Pterygium: an update on pathophysiology, clinical features, and management.Therapeutic advances in ophthalmologyReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify the pathogenic genes in pterygium.
methodsWe obtained mRNA expression profiles from the Gene Expression Omnibus database (GEO) to identify differentially expressed genes (DEGs) between pterygium tissues and normal conjunctiva tissues. The Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway analysis, protein-protein interaction (PPI) network and transcription factors (TFs)-target gene regulatory network was performed to understand the function of DEGs. The expression of selected DEGs were validated by the quantitative real-time polymerase chain reaction (qRT-PCR).
resultsA total of 557 DEGs were identified between pterygium and normal individual. In PPI network, several genes were with high degrees such as
conclusionThe deregulated genes might be involved in the pathology of pterygium and could be used as treatment targets for pterygium.
Indexed as
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What OpenQuestion holds
Registered trials
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