ArticleVirus evolution2019
Viral invasion fitness across a continuum from lysis to latency.
Article in Virus evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 79 citations in OpenAlex.
- Revisiting the life cycle of temperate phages.Nature reviews. Microbiology · 2026Review
- Host physiology-dependent lysis timing shapes bacteriophage competition under nutrient fluctuations.mSystems · 2026Article
- Biofilm spatial structure and superinfection immunity modulate inter-phage competition.PLoS biology · 2026Article
- Prophage: agent provocateur?Archives of microbiology · 2026Review
- Host life-history strategy is a critical determinant of virulent phage infection propensity.The ISME journal · 2026Article
- Temperate phage evolve to integrate host stress and quorum signals in lysis-lysogeny decisions.PLoS biology · 2026Article
- The adaptive plasticity of temperate phageVirus evolution · 2026Article
- Complex viral interactions revealed for the harmful bloom-forming dinoflagellateISME communications · 2026Article
- Viral Dark Matter: Illuminating Protein Function, Ecology, and Biotechnological Promises.Biochemistry · 2025Review
- A previously undescribed archaeal virus suppresses host immunity.EMBO reports · 2025Article
- Bistability between acute and chronic states in a Model of Hepatitis B Virus Dynamics.Mathematical biosciences · 2025Article
- Spatial propagation of temperate phages within and among biofilms.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Eco-evolutionary dynamics of temperate phages in periodic environments.Virus evolution · 2025Article
- Integrating viruses into soil food web biogeochemistry.Nature microbiology · 2024Review
- Lytic/Lysogenic Transition as a Life-History Switch.Virus evolution · 2024Article
- Pathogens and Passengers: Roles for Crustacean Zooplankton Viruses in the Global Ocean.Microorganisms · 2023Review
- Mutation-induced infections of phage-plasmids.Nature communications · 2023Article
- Using compartmental models and Particle Swarm Optimization to assess Dengue basic reproduction numberHeliyon · 2023Article
- Mutualistic interplay between bacteriophages and bacteria in the human gut.Nature reviews. Microbiology · 2022Review
- Protection of bacteriophage-sensitiveProceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevailing paradigm in ecological studies of viruses and their microbial hosts is that the reproductive success of viruses depends on the proliferation of the 'predator', that is, the virus particle. Yet, viruses are obligate intracellular parasites, and the virus genome-the actual unit of selection-can persist and proliferate from one cell generation to the next without lysis or the production of new virus particles. Here, we propose a theoretical framework to quantify the invasion fitness of viruses using an epidemiological cell-centric metric that focuses on the proliferation of viral genomes inside cells instead of virus particles outside cells. This cell-centric metric enables direct comparison of viral strategies characterized by obligate killing of hosts (e.g. via lysis), persistence of viral genomes inside hosts (e.g. via lysogeny), and strategies along a continuum between these extremes (e.g. via chronic infections). As a result, we can identify environmental drivers, life history traits, and key feedbacks that govern variation in viral propagation in nonlinear population models. For example, we identify threshold conditions given relatively low densities of susceptible cells and relatively high growth rates of infected cells in which lysogenic and other chronic strategies have higher potential viral reproduction than lytic strategies. Altogether, the theoretical framework helps unify the ongoing study of eco-evolutionary drivers of viral strategies in natural environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.