Evidence map›Paper›PMID 31024681›Full record

ArticleJournal of tissue engineering

Chronic optical pacing conditioning of h-iPSC engineered cardiac tissues.

Marc Dwenger, William J Kowalski, Fei Ye, Fangping Yuan, Joseph P Tinney, Shuji Setozaki, Takeichiro Nakane, Hidetoshi Masumoto, Peter Campbell, William Guido and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Cardiac optogenetics: shining light on signaling pathways.Pflugers Archiv : European journal of physiology · 2023
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Optogenetics for light control of biological systems.Nature reviews. Methods primers · 2022
    Article
  12. Article
  13. Cardiac optogenetics: a decade of enlightenment.Nature reviews. Cardiology · 2021
    Review
  14. Current Topics of Optogenetics for Medical Applications Toward Therapy.Advances in experimental medicine and biology · 2021
    Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Marc DwengerKosair Charities Pediatric Heart Research Program, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.
William J KowalskiKosair Charities Pediatric Heart Research Program, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.
Fei YeKosair Charities Pediatric Heart Research Program, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.
Fangping YuanKosair Charities Pediatric Heart Research Program, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.
Joseph P TinneyKosair Charities Pediatric Heart Research Program, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.
Shuji SetozakiKosair Charities Pediatric Heart Research Program, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.
Takeichiro NakaneKosair Charities Pediatric Heart Research Program, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.
Hidetoshi MasumotoDepartment of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Peter CampbellDepartment of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY, USA.
William GuidoDepartment of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY, USA.
Bradley B KellerKosair Charities Pediatric Heart Research Program, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.ORCID https://orcid.org/0000-0001-5476-6050
University of Louisville · USKyoto University · JPNational Institutes of Health · US

Funding

FUNCTIONAL STATE OF DEVELOPING RETINOGENICULATE SYNAPSER01EY012716 · NEI · VIRGINIA COMMONWEALTH UNIVERSITY · PI GUIDO, WILLIAM · 2001 to 2021
$6.9M
Formation and Maturation of Projections Between Thalamic Reticular Nucleus and Dorsal Lateral Geniculate NucleusF30EY026792 · NEI · UNIVERSITY OF LOUISVILLE · PI CAMPBELL, PETER W · 2017 to 2020
$161k
NEI NIH HHS F30 EY026792NEI NIH HHS R01 EY012716
6 · The paper itself

Abstract

The immaturity of human induced pluripotent stem cell derived engineered cardiac tissues limits their ability to regenerate damaged myocardium and to serve as robust

Indexed as

Channelrhodopsinengineered cardiac tissuesoptical pacingoptogeneticsstem cells

Identifiers

PMID31024681
PMCPMC6472158
OpenAlexW2937014246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.