Evidence map›Paper›PMID 31024575›Full record

ArticleFrontiers in immunology2019

BKV Clearance Time Correlates With Exhaustion State and T-Cell Receptor Repertoire Shape of BKV-Specific T-Cells in Renal Transplant Patients.

Ulrik Stervbo, Mikalai Nienen, Benjamin J D Weist, Leon Kuchenbecker, Jochen Hecht, Patrizia Wehler, Timm H Westhoff, Petra Reinke, Nina Babel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

  1. T-Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
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  7. Early clearance of BK polyomavirus-DNAemia among kidney transplant recipients may lead to better graft survival.Transplant infectious disease : an official journal of the Transplantation Society · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Robust hepatitis B vaccine-reactive T cell responses in failed humoral immunity.Molecular therapy. Methods & clinical development · 2021
    Article
  17. Review
  18. Review
  19. Observational
  20. COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activated Memory/Effector T Cells Expressing CD11aMolecular therapy : the journal of the American Society of Gene Therapy · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Ulrik StervboCenter for Translational Medicine, Medical Clinic I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany.
Mikalai NienenBerlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Benjamin J D WeistBerlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Leon KuchenbeckerApplied Bioinformatics, Center for Bioinformatics Tübingen, University of Tübingen, Tübingen, Germany.
Jochen HechtCentre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.
Patrizia WehlerBerlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Timm H WesthoffCenter for Translational Medicine, Medical Clinic I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany.
Petra ReinkeBerlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Nina BabelCenter for Translational Medicine, Medical Clinic I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany.
Freie Universität Berlin · DEHumboldt-Universität zu Berlin · DEUniversitätsklinik Marien Hospital Herne · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DECentre for Genomic Regulation · ESUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactivation of the BK polyomavirus is known to lead to severe complications in kidney transplant patients. The current treatment strategy relies on decreasing the immunosuppression to allow the immune system to clear the virus. Recently, we demonstrated a clear association between the resolution of BKV reactivation and reconstitution of BKV-specific CD4

Indexed as

Kidney TransplantationAdultAgedBK VirusCD4-Positive T-LymphocytesHumansImmunocompromised HostMaleMiddle AgedPolyomavirus InfectionsTumor Virus InfectionsVirus ActivationBKVdiversityexhaustionimmunologyT-cellTCR repertoire

Identifiers

PMID31024575
PMCPMC6468491
OpenAlexW2952506920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.