Trial reportFrontiers in immunology2019
The Number of Donor-Specific IL-21 Producing Cells Before and After Transplantation Predicts Kidney Graft Rejection.
2 registry-linked trialsOpen access · goldAbstract readClinical Trial
In one paragraph
Trial report in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Immune-response and Safety of COVID-19 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant - A Prospective, Controlled, Multicenter Cohort Study by the RECOVAC Consortium
The RECOVAC LESS CoV-2 Study - Long Term Efficacy and Safety of SARS-CoV-2 Vaccination in Patients in Patients With Chronic Kidney Disease Stage G4-G5, on Dialysis or After Kidney Transplantation
Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- The effects of interleukin-21 in the biology of transplant rejection.Frontiers in immunology · 2025Review
- IL-21-producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts.JCI insight · 2023Article
- Polyfunctional donor-reactive T cells are associated with acute T-cell-mediated rejection of the kidney transplant.Clinical and experimental immunology · 2023Article
- Alloreactive T cells to Assess Acute Rejection Risk in Kidney Transplant Recipients.Transplantation direct · 2023Article
- Proteomics for Biomarker Discovery for Diagnosis and Prognosis of Kidney Transplantation Rejection.Proteomes · 2022Review
- Immune Subsets From Ficoll Density Gradient Separation in Kidney Transplant Recipients.Transplantation direct · 2022Article
- Adaptive immune cell responses as therapeutic targets in antibody-mediated organ rejection.Trends in molecular medicine · 2022Review
- Targeting T Follicular Helper Cells to Control Humoral Allogeneic Immunity.Transplantation · 2021Review
- The RECOVAC IR study: the immune response and safety of the mRNA-1273 COVID-19 vaccine in patients with chronic kidney disease, on dialysis or living with a kidney transplant.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Article
- T-bet+CD27+CD21- B cells poised for plasma cell differentiation during antibody-mediated rejection of kidney transplants.JCI insight · 2021Article
- Pre-transplant donor-reactive IL-21 producing T cells as a tool to identify an increased risk for acute rejection.Scientific reports · 2021Observational
- Approaches for Controlling Antibody-Mediated Allograft Rejection Through Targeting B Cells.Frontiers in immunology · 2021Review
- Disruption of Tfh:B Cell Interactions Prevents Antibody-Mediated Rejection in a Kidney Transplant Model in Rats: Impact of Calcineurin Inhibitor Dose.Frontiers in immunology · 2021Article
- Natural Antibodies and Alloreactive T Cells Long after Kidney Transplantation.Journal of transplantation · 2021Article
- Review
- Immunosuppression Has Long-Lasting Effects on Circulating Follicular Regulatory T Cells in Kidney Transplant Recipients.Frontiers in immunology · 2020Article
- Review
- Increased circulating Tfh to Tfr ratio in chronic renal allograft dysfunction: a pilot study.BMC immunology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Nicole M van BesouwThe Rotterdam Transplant Group, Department of Internal Medicine-Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Lin YanThe Rotterdam Transplant Group, Department of Internal Medicine-Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Ronella de KuiperThe Rotterdam Transplant Group, Department of Internal Medicine-Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Mariska KlepperThe Rotterdam Transplant Group, Department of Internal Medicine-Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Derek ReijerkerkThe Rotterdam Transplant Group, Department of Internal Medicine-Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Marjolein DieterichThe Rotterdam Transplant Group, Department of Internal Medicine-Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Dave L RoelenDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands.
Frans H J ClaasDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands.
Marian C Clahsen-van GroningenThe Rotterdam Transplant Group, Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Dennis A HesselinkThe Rotterdam Transplant Group, Department of Internal Medicine-Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Carla C BaanThe Rotterdam Transplant Group, Department of Internal Medicine-Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Erasmus MC · NLLeiden University Medical Center · NLWest China Hospital of Sichuan University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin (IL)-21 supports induction and expansion of CD8
Indexed as
AdultAgedCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesEnzyme-Linked Immunospot AssayFemaleGraft RejectionHumansInterleukin-21InterleukinsKidney DiseasesKidney TransplantationLeukocytes, MononuclearMaleMiddle AgedTissue DonorsInterleukin-21InterleukinsbiomarkerElispotend-stage renal diseaseIL-21kidney transplantationrejection
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT04741386ClinicalTrials.gov
NCT04841785ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.