Evidence map›Paper›PMID 31024558›Full record

ArticleFrontiers in immunology2019

Adeno-Associated Virus as an Effective Malaria Booster Vaccine Following Adenovirus Priming.

Yenni Yusuf, Tatsuya Yoshii, Mitsuhiro Iyori, Kunitaka Yoshida, Hiroaki Mizukami, Shinya Fukumoto, Daisuke S Yamamoto, Asrar Alam, Talha Bin Emran, Fitri Amelia and 5 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Neo-antigen tumor vaccination depends on CD4-licensing conveyed by adeno-associated virus like particles.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Efforts to Develop Pfs25 Vaccines.The American journal of tropical medicine and hygiene · 2022
    Article
  11. Article
  12. Gene therapy access: Global challenges, opportunities, and views from Brazil, South Africa, and India.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Review
  13. Review
  14. Article
  15. Article
  16. Advancements in protein nanoparticle vaccine platforms to combat infectious disease.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021
    Review
  17. Article
  18. Review
  19. Liver-Directed AAV8 Booster Vaccine ExpressingFrontiers in immunology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Yenni YusufLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Tatsuya YoshiiLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Mitsuhiro IyoriLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Kunitaka YoshidaKanazawa University Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Hiroaki MizukamiDivision of Gene therapy, Jichi Medical University, Shimotsuke, Japan.
Shinya FukumotoNational Research Centre for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Daisuke S YamamotoDivision of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, Shimotsuke, Japan.
Asrar AlamLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Talha Bin EmranLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Fitri AmeliaLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Ashekul IslamLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Hiromu OtsukaLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Eizo TakashimaDivision of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Japan.
Takafumi TsuboiDivision of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Japan.
Shigeto YoshidaLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Kanazawa University · JPEhime University · JPJichi Medical University · JPHasanuddin University · IDObihiro University of Agriculture and Veterinary Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An ideal malaria vaccine platform should potently induce protective immune responses and block parasite transmission from mosquito to human, and it should maintain these effects for an extended period. Here, we have focused on vaccine development based on adeno-associated virus serotype 1 (AAV1), a viral vector widely studied in the field of clinical gene therapy that is able to induce long-term transgene expression without causing toxicity

Indexed as

AnimalsAntibodies, ProtozoanCells, CulturedDependovirusDisease ResistanceGenetic TherapyGenetic VectorsHumansImmunity, HeterologousImmunization, SecondaryMalariaMalaria VaccinesMiceMice, Inbred BALB CPlasmodium falciparumProtozoan ProteinsAntibodies, Protozoancircumsporozoite protein, ProtozoanMalaria VaccinesPfs25 protein, Plasmodium falciparumProtozoan Proteinsadeno-associated virushuman adenovirus serotype 5malaria vaccinePfs25Plasmodium falciparum circumsporozoite proteintransmission-blocking

Identifiers

PMID31024558
PMCPMC6460511
OpenAlexW2933655368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.