Evidence map›Paper›PMID 31024553›Full record

ReviewFrontiers in immunology2019

The Maintenance of Memory Plasma Cells.

Laleh Khodadadi, Qingyu Cheng, Andreas Radbruch, Falk Hiepe

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed
18.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 222 citations in OpenAlex.

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  12. Dynamics of memory B cells and plasmablasts in healthy individuals.Proceedings of the National Academy of Sciences of the United States of America · 2026
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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Laleh KhodadadiDeutsches Rheuma-Forschungszentrum Berlin-A Leibniz Institute, Berlin, Germany.
Qingyu ChengDeutsches Rheuma-Forschungszentrum Berlin-A Leibniz Institute, Berlin, Germany.
Andreas RadbruchDeutsches Rheuma-Forschungszentrum Berlin-A Leibniz Institute, Berlin, Germany.
Falk HiepeDeutsches Rheuma-Forschungszentrum Berlin-A Leibniz Institute, Berlin, Germany.
German Rheumatism Research Centre · DECharité - Universitätsmedizin Berlin · DEFreie Universität Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is now well accepted that plasma cells can become long-lived (memory) plasma cells and secrete antibodies for months, years or a lifetime. However, the mechanisms involved in this process of humoral memory, which is crucial for both protective immunity and autoimmunity, still are not fully understood. This article will address a number of open questions. For example: Is longevity of plasma cells due to their intrinsic competence, extrinsic factors, or a combination of both? Which internal signals are involved in this process? What factors provide external support? What survival factors play a part in inflammation and autoreactive disease? Internal and external factors that contribute to the maintenance of memory long-lived plasma cells will be discussed. The aim is to provide useful additional information about the maintenance of protective and autoreactive memory plasma cells that will help researchers design effective vaccines for the induction of life-long protection against infectious diseases and to efficiently target pathogenic memory plasma cells.

Indexed as

AnimalsAntibodiesCell SurvivalCellular MicroenvironmentCommunicable Disease ControlHumansImmunity, HumoralImmunologic MemoryPlasma CellsVaccinesAntibodiesVaccinesautoreactivitybone marrowinflammationlong-lived plasma cellsmaintenancememory plasma cellsplasma cellssurvival

Identifiers

PMID31024553
PMCPMC6464033
OpenAlexW2932960192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.