Evidence map›Paper›PMID 31024528›Full record

ArticleFrontiers in immunology2019

Bifunctional Small Molecules Enhance Neutrophil Activities Against

Caroline N Jones, Felix Ellett, Anne L Robertson, Kevin M Forrest, Kevin Judice, James M Balkovec, Martin Springer, James F Markmann, Jatin M Vyas, H Shaw Warren and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  3. Journal of oral microbiology · 2023
    Article
  4. Neutrophil dysfunction in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2021
    Article
  5. Article
  6. Immune Cell Paracrine Signaling Drives the Neutrophil Response toCellular and molecular bioengineering · 2021
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Leveraging the zebrafish to model organ transplantation.Current opinion in organ transplantation · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Caroline N JonesBioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Felix EllettBioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Anne L RobertsonBoston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Kevin M ForrestCidara Therapeutics, San Diego, CA, United States.
Kevin JudiceCidara Therapeutics, San Diego, CA, United States.
James M BalkovecCidara Therapeutics, San Diego, CA, United States.
Martin SpringerCidara Therapeutics, San Diego, CA, United States.
James F MarkmannBioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Jatin M VyasDivision of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
H Shaw WarrenDivision of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Daniel IrimiaBioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Funding

Bio-MicroElectroMechanical Systems Resource CenterP41EB002503 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI TONER, MEHMET · 2004 to 2018
$17.4M
Neutrophil Decision Making in Confined Environments in Health and DiseaseR01GM092804 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI IRIMIA, DANIEL · 2010 to 2022
$4.3M
NIBIB NIH HHS P41 EB002503NIGMS NIH HHS R01 GM092804
6 · The paper itself

Abstract

Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients. Neutrophils play a critical role in control of infection but may be diminished in number and function during immunosuppressive therapies. Here, we measure the effect of three bifunctional small molecules that target

Indexed as

Drug Delivery SystemsAnimalsAspergillosisAspergillus fumigatusHumansNeutrophilsZebrafishAspergillus fumigatus (A. fumigatus)bifunctional moleculescloudbreakfungi (mycelium and spores)microfluidicneutrophilzebrafish

Identifiers

PMID31024528
PMCPMC6465576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.