ArticleFrontiers in neurology2019
Association of Increased Serum S100B Levels With High School Football Subconcussive Head Impacts.
Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Repetitive Head Impacts During Contact Sports and Fluid Biomarkers of Neural Damage: A Meta-analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Head Impact Research Using Inertial Sensors in Sport: A Systematic Review of Methods, Demographics, and Factors Contributing to Exposure.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- The accumulation of subconcussive impacts on cognitive, imaging, and biomarker outcomes in child and college-aged athletes: a systematic review.Brain imaging and behavior · 2022Pooled it
- GFAP and S100B: What You Always Wanted to Know and Never Dared to Ask.Frontiers in neurology · 2022Pooled it
- Peripheral Blood and Salivary Biomarkers of Blood-Brain Barrier Permeability and Neuronal Damage: Clinical and Applied Concepts.Frontiers in neurology · 2020Pooled it
- Does acute soccer heading cause an increase in plasma S100B? A randomized controlled trial.PloS one · 2020Trial
- Advances in research on biomaterials and stem cell/exosome-based strategies in the treatment of traumatic brain injury.Acta pharmaceutica Sinica. B · 2025Review
- Association of blood biomarkers for neural injury with recent, frequent exposure to partnered sexual strangulation in young adult women.The journal of sexual medicine · 2025Article
- Assessing the capability of the corneal blink reflex to display neurological changes following subconcussive head impacts.Frontiers in neurology · 2025Article
- Effects of Lifetime Exposure to Sports-Related Head Impacts on Brain Injury and Inflammatory Blood Biomarkers Among Former Middle-Aged Athletes.Neurotrauma reports · 2025Article
- Article
- Multiparameter cortical surface morphology in former amateur contact sport athletes.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A Pilot Study Investigating the Use of Serum Glial Fibrillary Acidic Protein to Monitor Changes in Brain White Matter Integrity After Repetitive Head Hits During a Single Collegiate Football Game.Journal of neurotrauma · 2024Article
- The effect of high-intensity intermittent and moderate-intensity continuous exercises on neurobiological markers and cognitive performance.BMC sports science, medicine & rehabilitation · 2024Article
- The Use of Biofluid Markers to Evaluate the Consequences of Sport-Related Subconcussive Head Impact Exposure: A Scoping Review.Sports medicine - open · 2024Article
- Article
- Association Between Serum Neurofilament Light and Glial Fibrillary Acidic Protein Levels and Head Impact Burden in Women's Collegiate Water Polo.Journal of neurotrauma · 2023Observational
- S100B, Actor and Biomarker of Mild Traumatic Brain Injury.International journal of molecular sciences · 2023Review
- Longitudinal, prospective study of head impacts in male high school football players.PloS one · 2023Article
- Drill Intensity and Head Impact Exposure in Adolescent Football.Pediatrics · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astrocyte-enriched marker, S100B, shows promise for gauging the severity of acute brain trauma, and understanding subconcussive effects will advance its utility in tracking real-time acute brain damage. The aim of the study was to investigate whether serum S100B elevations were associated with frequency and magnitude of subconcussive head impacts in adolescents. This prospective cohort study of 17 high-school football players consisted of the following 12 time points: pre-season baseline, 5 in-season pre-post games, and post-season. A sensor-installed mouthguard recorded the number of head impacts, peak linear (PLA) and peak rotational (PRA) head accelerations from every practice and game. During the 5 games, players wore chest-strap heart-rate monitors to estimate players' excess post-exercise oxygen consumption (EPOC), accounting for physical exertion effects. At each time point, blood samples were obtained and assessed for S100B and creatine kinase levels to account for astrocyte damage/activation and muscle damage, respectively. Using
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.