ArticleFrontiers in physiology2019
Cerebral Perfusion Changes After Osteopathic Manipulative Treatment: A Randomized Manual Placebo-Controlled Trial.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07629765 (Exploring the Impact of Osteopathic Manipulative Treatment on CSF Dynamics), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploring the Impact of Osteopathic Manipulative Treatment on CSF Dynamics: A Mechanistic MRI-Based Investigation
Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Effect of osteopathic techniques on human resting muscle tone in healthy subjects using myotonometry: a factorial randomized trial.Scientific reports · 2022Trial
- The efficacy of mechanical spinal manipulation in the standing position in patients with non-specific low back pain: a randomised placebo-controlled trial.Archives of medical science : AMS · 2026Article
- Impact of touch interventions on brain activity in moderately preterm infants: study protocol for a pilot randomised controlled trial.BMJ open · 2025Article
- Acute Effects of Osteopathic Treatment in Long COVID-19 Patients with Fatigue Symptoms: A Randomized, Controlled Trial.Journal of clinical medicine · 2025Article
- The Effect of Osteopathic Visceral Manipulation on Quality of Life and Postural Stability in Women with Endometriosis and Women with Pelvic Organ Prolapse: A Non-Controlled Before-After Clinical Study.Journal of clinical medicine · 2025Article
- The Effects of Osteopathic Manipulative Treatment on Brain Activity: A Scoping Review of MRI and EEG Studies.Healthcare (Basel, Switzerland) · 2024Article
- Neurophysiology, Neuro-Immune Interactions, and Mechanobiology in Osteopathy in the Cranial Field: An Evidence-Informed Perspective for a Scientific Rationale.Healthcare (Basel, Switzerland) · 2023Article
- Reconceptualizing Somatic Dysfunction in the Light of a Neuroaesthetic Enactive Paradigm.Healthcare (Basel, Switzerland) · 2023Article
- Beliefs and Use of Palpatory Findings in Osteopathic Clinical Practice: A Qualitative Descriptive Study among Italian Osteopaths.Healthcare (Basel, Switzerland) · 2022Article
- The Role of Osteopathic Care in Gynaecology and Obstetrics: An Updated Systematic Review.Healthcare (Basel, Switzerland) · 2022Review
- Neurogenic Bowel Dysfunction Changes after Osteopathic Care in Individuals with Spinal Cord Injuries: A Preliminary Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2022Article
- Therapeutic Alliance as Active Inference: The Role of Therapeutic Touch and Biobehavioural Synchrony in Musculoskeletal Care.Frontiers in behavioral neuroscience · 2022Article
- Osteopathic Care as (En)active Inference: A Theoretical Framework for Developing an Integrative Hypothesis in Osteopathy.Frontiers in psychology · 2022Article
- International Overview of Somatic Dysfunction Assessment and Treatment in Osteopathic Research: A Scoping Review.Healthcare (Basel, Switzerland) · 2021Article
- Osteopathic Models Integration Radar Plot: A Proposed Framework for Osteopathic Diagnostic Clinical Reasoning.Journal of chiropractic humanities · 2021Review
- The Immediate Effect of Informational Manual Therapy for Improving Quiet Standing and Bodily Pain in University Population.International journal of environmental research and public health · 2021Article
- Osteopathy modulates brain-heart interaction in chronic pain patients: an ASL study.Scientific reports · 2021Article
- Osteopathy and Mental Health: An Embodied, Predictive, and Interoceptive Framework.Frontiers in psychology · 2021Article
- Brain Connectivity Changes after Osteopathic Manipulative Treatment: A Randomized Manual Placebo-Controlled Trial.Brain sciences · 2020Article
- Evidence-based assessment of potential therapeutic effects of adjunct osteopathic medicine for multidisciplinary care of acute and convalescent COVID-19 patients.Explore (New York, N.Y.)Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteopathic Manipulative Treatment (OMT) is a therapeutic approach aimed at enhancing the body's self-regulation focusing on somatic dysfunctions correction. Despite evidence of OMT effectiveness, the underlying neurophysiological mechanisms, as well as blood perfusion effects, are still poorly understood. The study aim was to address OMT effects on cerebral blood flow (CBF) in asymptomatic young volunteers as measured by Magnetic Resonance Arterial Spin Labeling (ASL) method. Thirty blinded participants were randomized to OMT or placebo, and evaluated with an MRI protocol before manual intervention (T0), immediately after (T1), and 3 days later (T2). After T0 MRI, participants received 45 min of OMT, focused on correcting whole body somatic dysfunctions, or placebo manual treatment, consisting of passive touches in a protocolled order. After treatment, participants completed a de-blinding questionnaire about treatment perception. Results show significant differences due to treatment only for the OMT group (OMTg): perfusion decreased (compared to T0) in a cluster comprising the left posterior cingulate cortex (PCC) and the superior parietal lobule, while increased at T2 in the contralateral PCC. Furthermore, more than 60% of participants believed they had undergone OMT. The CBF modifications at T2 suggest that OMT produced immediate but reversible effects on CBF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.