ArticleFrontiers in physiology2019
Effect of Superior Ovarian Nerve and Plexus Nerve Sympathetic Denervation on Ovarian-Derived Infertility Provoked by Estradiol Exposure to Rats.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Real-Time and High-Resolution NIR-II-L Imaging of Netrin-1-Mediated Neurovascular Coupling Driven by Dose-Dependent Electroacupuncture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Sensory neuron LKB1 mediates ovarian and reproductive function.Scientific reports · 2024Article
- Metabolic control of ovarian function through the sympathetic nervous system: role of leptin.Frontiers in endocrinology · 2024Review
- Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation.Frontiers in endocrinology · 2023Article
- The role of the autonomic nervous system in polycystic ovary syndrome.Frontiers in endocrinology · 2023Review
- Gestational Sympathetic Stress Programs the Fertility of Offspring: A Rat Multi-Generation Study.International journal of environmental research and public health · 2022Article
- rno-miR-128-3p promotes apoptosis in rat granulosa cells (GCs) induced by norepinephrine through Wilms tumor 1 (WT1).In vitro cellular & developmental biology. Animal · 2021Article
- Nerve Growth Factor: A Dual Activator of Noradrenergic and Cholinergic Systems of the Rat Ovary.Frontiers in endocrinology · 2021Article
- Cardiovascular Properties of the Androgen-Induced PCOS Model in Rats: The Role of Oxidative Stress.Oxidative medicine and cellular longevity · 2021Article
- Ovarian Innervation Coupling With Vascularity: The Role of Electro-Acupuncture in Follicular Maturation in a Rat Model of Polycystic Ovary Syndrome.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sympathetic innervation of the ovary in rodents occurs via two routes: the superior ovarian nerve (SON), which runs along the ovarian ligament, and the plexus nerve (PN), which is mainly associated with the vasculature. SON and ovarian norepinephrine (NE) levels play a major role in regulating ovarian cystic health. Although it was previously described that the polycystic ovarian phenotype (PCO) is causally related to hyperstimulation of the sympathetic nerves of the ovary, much less is known, however, regarding the role of PN in ovarian physiology. We studied the role of SON and PN in relation to the maintenance of the PCO phenotype induced in the rat by exposure to estradiol valerate (EV). EV exposure at 24 days old (juvenile exposure) increases NE in the ovary for up to 90 days after EV injection. SON or PN denervation (SONX and PNX) decreased NE. SONXreversed the acyclic condition from 30 days after surgery (
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