Evidence map›Paper›PMID 31024207›Full record

ReviewJournal of clinical and experimental hepatology

Rupture of Hepatocellular Carcinoma: A Review of Literature.

Srimanta K Sahu, Yogesh K Chawla, Radha K Dhiman, Virendra Singh, Ajay Duseja, Sunil Taneja, Naveen Kalra, Ujjwal Gorsi

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 129 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Early Hemostatic Treatment Could Improve 30-Day Survival After Spontaneous Rupture of Hepatocellular Carcinoma.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Observational
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Srimanta K SahuDepartment of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Yogesh K ChawlaDepartment of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Radha K DhimanDepartment of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Virendra SinghDepartment of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Ajay DusejaDepartment of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Sunil TanejaDepartment of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Naveen KalraDepartment of Radio Diagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Ujjwal GorsiDepartment of Radio Diagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 700,000 people die of Hepatocellular Carcinoma (HCC) each year worldwide, making it the third leading cause of cancer related deaths. Rupture is a potentially life-threatening complication of HCC. The incidence of HCC rupture is higher in Asia and Africa than in Europe. In Asia approximately 10% of patients with a diagnosis of HCC die due to rupture each year. Spontaneous rupture is the third most common cause of death due to HCC after tumor progression and liver failure. The diagnosis of rupture in patients without history of cirrhosis or HCC may be difficult. The most common symptom of ruptured HCC is abdominal pain (66-100%). Shock at presentation can be seen in 33-90% of cases; abdominal distension is reported in 33%. Abdominal paracentesis documenting hemoperitoneum is a reliable test to provisionally diagnose rupture of HCC, it can be seen in up to 86% of clinically suspected cases. The diagnoses can be confirmed by computed tomography scan or ultrasonography, or both in 75% of cases. Careful pre-treatment evaluation is essential to decide the best treatment option. Management of ruptured HCC involves multi-disciplinary care where hemostasis remains a primary concern. Earlier studies have reported a mortality rate of 25-75% in the acute phase of ruptured HCC. However, recent studies have reported a significant decrease in the incidence of mortality. There is also a decrease in the incidence of ruptured HCC due to improved surveillance and early detection of HCC. Transarterial Embolization is the least invasive method to effectively induce hemostasis in the acute stage with a success rate of 53-100%. Hepatic resection in the other hand has the advantage of achieving hemostasis and in the same go offers a potentially curative resection in selected patients.

Indexed as

CTP, Child Turcotte PughHBV, Hepatitis B VirusHCC, Hepatocellular CarcinomaHCV, Hepatitis C Virushemoperitoneumhepatocellular carcinomaspontaneous ruptureTACE, Trans-arterial Chemo-embolizationTAE, Transarterial Embolizationtransarterial embolizationVEGF, Vascular Endothelial Growth Factor

Identifiers

PMID31024207
PMCPMC6476943
OpenAlexW2799811536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.