ArticleJournal of clinical and experimental hepatology
A/H1N1/09 Influenza is Associated With High Mortality in Liver Cirrhosis.
Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04668404 (Study of Coagulation Profile and Role of Heparin-like Effect in Patients With COVID-19), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of Coagulation Profile and Role of Heparin-like Effect in Patients With COVID-19
Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Trends and factors associated with liver fibrosis-cirrhosis complicated with pneumonia-influenza mortality in U.S. Counties: a CDC WONDER and CHR database analysis.Frontiers in public health · 2026Article
- Clinical practice guidelines for the treatment and prophylaxis of influenza in China (2025 edition).Infectious diseases & immunity · 2026Article
- Clinical Characteristics Associated with Mortality in Children with Critically Ill Influenza B in the Pediatric Intensive Care Unit.Infection and drug resistance · 2026Article
- A discrete SIR epidemic model incorporating media impact, resource limitaions and threshold switching strategies.Infectious Disease Modelling · 2025Article
- Vaccine effectiveness against influenza-associated hospitalizations in adults with liver disease, 2015-2020: US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN).Human vaccines & immunotherapeutics · 2025Article
- Non hepatotropic virus induced hepatitis - rising importance in a changing world.World journal of virology · 2025Review
- Post COVID Condition and Long-Term COVID-19 Impact on Hepatic Decompensation and Survival in Cirrhosis: A Propensity Matched Observational Study.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Immune Response and Risk of Decompensation following SARS-CoV-2 Infection in Outpatients with Advanced Chronic Liver Disease.International journal of molecular sciences · 2024Observational
- Review
- Respiratory tract viral infections associated sepsis in patients with underlying liver disease: Viral sepsis an entity to look forward!Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Article
- Influenza vaccination for elderly, vulnerable and high-risk subjects: a narrative review and expert opinion.Internal and emergency medicine · 2024Review
- Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis.Clinical and experimental immunology · 2024Article
- Vaccination in liver diseases and liver Transplantation: Recommendations, implications and opportunities in the post-covid era.JHEP reports : innovation in hepatology · 2023Review
- Machine learning for emerging infectious disease field responses.Scientific reports · 2022Article
- From advanced disease to transplantation: an overview of the liver at the time of COVID-19 pandemic.Internal and emergency medicine · 2022Review
- The impact of COVID-19 disease on the natural course of cirrhosis: Before and after starting vaccination.Frontiers in medicine · 2022Article
- Cytokine Storm of COVID-19 and Its Impact on Patients with and without Chronic Liver Disease.Journal of clinical and translational hepatology · 2021Review
- Influenza vaccination uptake and factors influencing vaccination decision among patients with chronic kidney or liver disease.PloS one · 2021Article
- High rates of 30-day mortality in patients with cirrhosis and COVID-19.Journal of hepatology · 2020Article
- Spectrum of respiratory viral infections in liver disease patients with cirrhosis admitted in critical care unit.Journal of laboratory physiciansArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsA/H1N1/09 influenza is associated with a high risk of complications in patients with chronic diseases. In view of patients with cirrhosis being recognized as another high-risk group for influenza morbidity and mortality, we report a cluster of suspected A/H1N1/09 infection in 110 patients admitted to a hepatology intensive care unit.
methodsThe pattern of spread, clinical outcome, and respiratory parameters of A/H1N1/09 of 22 positive cirrhotic patients were compared with those from a control group of 88 patients with chronic liver disease (CLD) with influenza-like pneumonia who tested negative for A/H1N1/09.
resultsA/H1N1/09 infection was confirmed in 22 (20%) patients. Eighteen of 22 (81.8%) CLD patients with A/H1N1/09 died of pneumonia and acute respiratory distress syndrome despite timely antiviral treatment. In contrast, only 35 (40%)of the control group of cirrhotic patients without A/H1N1/09 died. On univariate analysis, age > 45 years [OR 1.3; 95% CI 1.1-5.7, (
conclusionEarly detection and referral, and early antiviral treatment with a strict control of nosocomial spread is essential in patients with cirrhosis during epidemic influenza.
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