Evidence map›Paper›PMID 31024041›Full record

ArticleScientific reports2019

The risk of selenium deficiency in Malawi is large and varies over multiple spatial scales.

Felix P Phiri, E Louise Ander, Elizabeth H Bailey, Benson Chilima, Allan D C Chilimba, Jellita Gondwe, Edward J M Joy, Alexander A Kalimbira, Diriba B Kumssa, R Murray Lark and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.

  1. Elevated COFrontiers in plant science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Felix P PhiriSchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK. felixphiri8@gmail.com.
E Louise AnderInorganic Geochemistry, Centre for Environmental Geochemistry, British Geological Survey, Nottingham, NG12 5GG, UK.ORCID http://orcid.org/0000-0003-3901-1949
Elizabeth H BaileySchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK.ORCID http://orcid.org/0000-0002-5266-3792
Benson ChilimaCommunity Health Sciences Unit, Ministry of Health, Private Bag 65, Lilongwe, Malawi.
Allan D C ChilimbaThe Department of Agricultural Research Services, P.O. Box 30799, Lilongwe 3, Malawi.
Jellita GondweCommunity Health Sciences Unit, Ministry of Health, Private Bag 65, Lilongwe, Malawi.
Edward J M JoyFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Alexander A KalimbiraDepartment of Human Nutrition and Health, Faculty of Food and Human Sciences, Bunda Campus, Lilongwe University of Agriculture and Natural Resources, P.O. Box 219, Lilongwe, Malawi.
Diriba B KumssaSchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK.
R Murray LarkSchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK.
John C PhukaSchool of Public Health and Family Medicine, College of Medicine, University of Malawi, Private Bag 360, Chichiri, Blantyre 3, Malawi.
Andrew SalterSchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK.
Parminder S SuchdevDepartment of Pediatrics and Hubert Department of Global Health, Emory University, Atlanta, Georgia, 30322, USA.
Michael J WattsInorganic Geochemistry, Centre for Environmental Geochemistry, British Geological Survey, Nottingham, NG12 5GG, UK.ORCID http://orcid.org/0000-0003-0379-8401
Scott D YoungSchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK.
Martin R BroadleySchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK. martin.broadley@nottingham.ac.uk.
University of Nottingham · GBBritish Geological Survey · GBPublic Health Institute of Malawi · MWEmory University · USLilongwe University of Agriculture and Natural Resources · MWUniversity of London · GBUniversity of Malawi · MW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selenium (Se) is an essential human micronutrient. Deficiency of Se decreases the activity of selenoproteins and can compromise immune and thyroid function and cognitive development, and increase risks from non-communicable diseases. The prevalence of Se deficiency is unknown in many countries, especially in sub-Saharan Africa (SSA). Here we report that the risk of Se deficiency in Malawi is large among a nationally representative population of 2,761 people. For example, 62.5% and 29.6% of women of reproductive age (WRA, n = 802) had plasma Se concentrations below the thresholds for the optimal activity of the selenoproteins glutathione peroxidase 3 (GPx3; <86.9 ng mL

Indexed as

AdolescentAdultAge FactorsChildChild, PreschoolFemaleGlutathione PeroxidaseHumansMalawiMaleMiddle AgedReproductionSeleniumYoung AdultGlutathione PeroxidaseGPX3 protein, humanSelenium

Identifiers

PMID31024041
PMCPMC6484074
OpenAlexW2941867980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.