Evidence map›Paper›PMID 31023965›Full record

ArticleBioscience reports2019

Overexpression of thymic stromal lymphopoietin is correlated with poor prognosis in epithelial ovarian carcinoma.

Lu Xu, Yacong Guo, Ning Xu, Lihai Chen, Jin Zhu, Ningsheng Liu, Zhi-Yuan Zhang

Open access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. TSLP: contrasting roles in cancer.Frontiers in immunology · 2025
    Review
  2. Review
  3. TSLP, IL-33, and IL-25: Not just for allergy and helminth infection.The Journal of allergy and clinical immunology · 2022
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
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  12. TSLP: from allergy to cancer.Nature immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lu XuDepartment of Pathology, Nanjing Medical University, Nanjing 210000, China.
Yacong GuoDepartment of Pathology, Nanjing Medical University, Nanjing 210000, China.
Ning XuDepartment of Pathology, Nanjing Medical University, Nanjing 210000, China.
Lihai ChenDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210000, China.
Jin ZhuHuadong Medical Institute of Biotechniques, Nanjing 210002, China.
Ningsheng LiuDepartment of Pathology, Nanjing Medical University, Nanjing 210000, China zzy@njmu.edu.cn liuns@njmu.edu.cn.
Zhi-Yuan ZhangDepartment of Pathology, Nanjing Medical University, Nanjing 210000, China zzy@njmu.edu.cn liuns@njmu.edu.cn.ORCID 0000-0001-9067-0670
Nanjing Medical University · CNHuadong Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that has been reported to be associated with several malignant tumors. The present study aimed to evaluate its role in epithelial ovarian carcinoma (EOC). The mRNA levels of TSLP in human EOC samples and EOC cell lines were determined. Then, the expression of TSLP was examined in 144 clinical tissue microarray samples and correlated with clinicopathological factors. Finally, the correlation between TSLP overexpression and prognosis of EOC patients was analyzed. Our data show that mRNA levels of TSLP were significantly higher in EOC tissues and cell lines. Chi-square tests revealed that TSLP overexpression in EOC was significantly associated with age, histological type, Federation of Gynecology and Obstetrics (FIGO) stage, histological differentiation, pelvic involvement, and lymphatic metastasis. Kaplan-Meier survival analysis revealed that poor prognosis was significantly correlated with older age, advanced FIGO stage, poor histological differentiation, pelvic involvement, lymphatic involvement, or TSLP overexpression (

Indexed as

AdultAgedCarcinoma, Ovarian EpithelialCell Line, TumorCytokinesFemaleGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMiddle AgedOvarian NeoplasmsPrognosisThymic Stromal LymphopoietinUp-RegulationYoung AdultCytokinesThymic Stromal Lymphopoietinepithelial ovarian cancerimmunohistochemistryprognosisthymic stromal lymphopoietin

Identifiers

PMID31023965
PMCPMC6522712
OpenAlexW2940894470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.