Evidence map›Paper›PMID 31023875›Full record

ArticleDevelopment (Cambridge, England)2019

A single KH domain in Bicaudal-C links mRNA binding and translational repression functions to maternal development.

Megan E Dowdle, Sookhee Park, Susanne Blaser Imboden, Catherine A Fox, Douglas W Houston, Michael D Sheets

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. mRNA (New York, N.Y.) · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Bicaudal-C Post-transcriptional regulator of cell fates and functions.Frontiers in cell and developmental biology · 2022
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Megan E DowdleDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-8528-9875
Sookhee ParkDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-8758-4560
Susanne Blaser ImbodenDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-0021-6250
Catherine A FoxDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-6190-6207
Douglas W HoustonDepartment of Biology, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-3469-1546
Michael D SheetsDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA mdsheets@wisc.edu.ORCID 0000-0003-2523-4463
University of Wisconsin–Madison · USUniversity of Iowa · US

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
Origin Recognition Complex at Transcriptional SilencersR01GM056890 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, CATHERINE A · 1998 to 2020
$6.4M
Localized mRNAs in vertebrate axis formationR01GM083999 · NIGMS · UNIVERSITY OF IOWA · PI HOUSTON, DOUGLAS W · 2008 to 2016
$2.6M
Regulation of cell fates by the Bicaudal-C translational repressorR01HD091921 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SHEETS, MICHAEL D · 2018 to 2022
$1.5M
Defining the Xenopus translatomeR21HD076828 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SHEETS, MICHAEL D · 2013 to 2014
$393k
NICHD NIH HHS R01 HD091921NICHD NIH HHS R21 HD076828NIGMS NIH HHS R01 GM056890NIGMS NIH HHS R01 GM083999NIGMS NIH HHS T32 GM008349
6 · The paper itself

Abstract

Bicaudal-C (Bicc1) is a conserved RNA-binding protein that represses the translation of selected mRNAs to control development. In

Indexed as

3' Untranslated RegionsAnimalsEmbryonic DevelopmentFemaleImmunoblottingImmunoprecipitationProtein BindingRNA-Binding ProteinsRNA, MessengerXenopus laevisXenopus Proteins3' Untranslated RegionsBICC1 protein, XenopusRNA-Binding ProteinsRNA, MessengerXenopus ProteinsBicaudal-CMaternalmRNA translationPost-transcriptionalRepressionRNA binding

Identifiers

PMID31023875
PMCPMC6550016
OpenAlexW2940782091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.