Evidence map›Paper›PMID 31023823›Full record

ArticleThe Journal of biological chemistry2019

Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation.

Laura Pajed, Carina Wagner, Ulrike Taschler, Renate Schreiber, Stephanie Kolleritsch, Nermeen Fawzy, Isabella Pototschnig, Gabriele Schoiswohl, Lisa-Maria Pusch, Beatrix I Wieser and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. From LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2025
    Article
  3. Article
  4. Recent insights into lysosomal acid lipase deficiency.Trends in molecular medicine · 2023
    Review
  5. Review
  6. Therapeutic efficacy of rscAAVrh74.miniCMV.Molecular therapy. Methods & clinical development · 2022
    Article
  7. Review
  8. Article
  9. Review
  10. The role of β-carotene and vitamin A in atherogenesis: Evidences from preclinical and clinical studies.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Laura PajedFrom the Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstrasse 31/II.
Carina WagnerFrom the Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstrasse 31/II.
Ulrike TaschlerFrom the Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstrasse 31/II.
Renate SchreiberFrom the Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstrasse 31/II.
Stephanie KolleritschFrom the Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstrasse 31/II.
Nermeen FawzyFrom the Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstrasse 31/II.
Isabella PototschnigFrom the Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstrasse 31/II.
Gabriele SchoiswohlFrom the Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstrasse 31/II.
Lisa-Maria PuschFrom the Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstrasse 31/II.
Beatrix I Wieserthe Diagnostic and Research Center for Molecular BioMedicine, Institute of Pathology, Medical University of Graz.
Paul Veselythe Diagnostic and Research Center for Molecular BioMedicine, Institute of Pathology, Medical University of Graz.
Gerald Hoeflerthe Diagnostic and Research Center for Molecular BioMedicine, Institute of Pathology, Medical University of Graz.
Thomas O EichmannFrom the Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstrasse 31/II.
Robert ZimmermannFrom the Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstrasse 31/II.
Achim LassFrom the Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstrasse 31/II, achim.lass@uni-graz.at.ORCID 0000-0002-8190-7151
University of Graz · ATMedical University of Graz · AT

Funding

Austrian Science Fund FWF I 3535Austrian Science Fund FWF P 28882Austrian Science Fund FWF W 901
6 · The paper itself

Abstract

Lysosomal acid lipase (LAL) hydrolyzes cholesteryl ester (CE) and retinyl ester (RE) and triglyceride (TG). Mice globally lacking LAL accumulate CE most prominently in the liver. The severity of the CE accumulation phenotype progresses with age and is accompanied by hepatomegaly and hepatic cholesterol crystal deposition. In contrast, hepatic TG accumulation is much less pronounced in these mice, and hepatic RE levels are even decreased. To dissect the functional role of LAL for neutral lipid ester mobilization in the liver, we generated mice specifically lacking LAL in hepatocytes (hep-LAL-ko). On a standard chow diet, hep-LAL-ko mice exhibited increased hepatic CE accumulation but unaltered TG and RE levels. Feeding the hep-LAL-ko mice a vitamin A excess/high-fat diet (VitA/HFD) further increased hepatic cholesterol levels, but hepatic TG and RE levels in these mice were lower than in control mice. Performing

Indexed as

AnimalsCCAAT-Enhancer-Binding ProteinsCells, CulturedCholesterolCholesterol EstersDiet, High-FatDiterpenesHepatocytesLipidsLiverMiceMice, Inbred C57BLMice, KnockoutPhospholipidsSterol EsteraseTriglyceridesCCAAT-Enhancer-Binding ProteinsCEBPA protein, mouseCholesterolCholesterol EstersDiterpenesLipidslysosomal acid lipase, mousePhospholipidsSterol EsteraseTriglyceridesVitamin Acholesterolhepatocyteshyperlipidemia, metabolic disorderlipid metabolismliverlysosomal acid lipaselysosomeneutral lipid ester metabolismtriglyceridevitamin A

Identifiers

PMID31023823
PMCPMC6556574
OpenAlexW2942265549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.