ArticleGenome biology2019
Whole-genome sequence analysis of a Pan African set of samples reveals archaic gene flow from an extinct basal population of modern humans into sub-Saharan populations.
Article in Genome biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed.
- Recovering signatures of archaic introgression using ancestral recombination graphs.bioRxiv : the preprint server for biology · 2026Article
- GHIST 2024: The First Genomic History Inference Strategies Tournament.Molecular biology and evolution · 2025Article
- A structured coalescent model reveals deep ancestral structure shared by all modern humans.Nature genetics · 2025Article
- Insufficient Evidence for a Severe Bottleneck in Humans During the Early to Middle Pleistocene Transition.Molecular biology and evolution · 2025Article
- Archaic hominin admixture and its consequences for modern humans.Current opinion in genetics & development · 2025Review
- Linguistic capacity was present in theFrontiers in psychology · 2025Article
- Genome Tunisia Project: paving the way for precision medicine in North Africa.Genome medicine · 2024Article
- Modelling the demographic history of human North African genomes points to a recent soft split divergence between populations.Genome biology · 2024Article
- Computationally Efficient Demographic History Inference from Allele Frequencies with Supervised Machine Learning.Molecular biology and evolution · 2024Article
- Biogeographic Perspectives on Human Genetic Diversification.Molecular biology and evolution · 2024Article
- Computationally efficient demographic history inference from allele frequencies with supervised machine learning.bioRxiv : the preprint server for biology · 2024Article
- A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants.Science advances · 2023Article
- Multiple Sources of Uncertainty Confound Inference of Historical Human Generation Times.Molecular biology and evolution · 2023Article
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- Article
- Evolutionary Genetics and Admixture in African Populations.Genome biology and evolution · 2023Review
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- Denisovan introgression has shaped the immune system of present-day Papuans.PLoS genetics · 2022Article
- The contribution of Neanderthal introgression to modern human traits.Current biology : CB · 2022Review
- Cross-ethnic analysis of common gene variants in hemostasis show lopsided representation of global populations in genetic databases.BMC medical genomics · 2022Article
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12 authors.
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Abstract
backgroundPopulation demography and gene flow among African groups, as well as the putative archaic introgression of ancient hominins, have been poorly explored at the genome level.
resultsHere, we examine 15 African populations covering all major continental linguistic groups, ecosystems, and lifestyles within Africa through analysis of whole-genome sequence data of 21 individuals sequenced at deep coverage. We observe a remarkable correlation among genetic diversity and geographic distance, with the hunter-gatherer groups being more genetically differentiated and having larger effective population sizes throughout most modern-human history. Admixture signals are found between neighbor populations from both hunter-gatherer and agriculturalists groups, whereas North African individuals are closely related to Eurasian populations. Regarding archaic gene flow, we test six complex demographic models that consider recent admixture as well as archaic introgression. We identify the fingerprint of an archaic introgression event in the sub-Saharan populations included in the models (~ 4.0% in Khoisan, ~ 4.3% in Mbuti Pygmies, and ~ 5.8% in Mandenka) from an early divergent and currently extinct ghost modern human lineage.
conclusionThe present study represents an in-depth genomic analysis of a Pan African set of individuals, which emphasizes their complex relationships and demographic history at population level.
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