ArticleBMC pharmacology & toxicology2019
Quality of albendazole tablets legally circulating in the pharmaceutical market of Addis Ababa, Ethiopia: physicochemical evaluation.
Article in BMC pharmacology & toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- In vitro comparative quality evaluation of different brands of metformin hydrochloride tablets available in Mekelle City, Tigray Regional State, Ethiopia.BMC pharmacology & toxicology · 2026Article
- Prevalence of Unregistered, Substandard, and Falsified Veterinary Antimicrobials in Ethiopia: A National Postmarket Quality Surveillance Study.Veterinary medicine international · 2026Article
- Quality analysis of albendazole formulations available in veterinary pharmacies of Nepal.BMC pharmacology & toxicology · 2025Article
- Lessons from Ethiopian pharmaceutical regulation: a risk-based approach to overcome challenges and unlock opportunities.Frontiers in medicine · 2025Article
- Epidemiology and field efficacy of anthelmintic drugs associated with gastrointestinal nematodes of sheep in Nejo district, Oromia, Ethiopia.Scientific reports · 2024Article
- Evaluating the Knowledge, Practice, and Regulatory Situation of Veterinary Experts Regarding Counterfeit Veterinary Medications in the Selected Districts of Central Gondar Zone, Ethiopia.Veterinary medicine (Auckland, N.Z.) · 2024Article
- A narrative review on problems in product quality, regulatory system constraints, and the concept of quality by design as a solution for quality assurance of African medicines.Frontiers in medicine · 2024Review
- Quality of veterinary anthelmintic drugs marketed in Gondar Zones, North West Ethiopia; presence of poor-quality medicines.Heliyon · 2023Article
- Post marketing surveillance of selected veterinary medicines in Tanzania mainland.BMC veterinary research · 2022Article
- Prevalence and associated factors of gastrointestinal helminthiasis of lactating cow and effect of strategic deworming on milk quantity, fat, and protein in Kucha, Ethiopia.BMC veterinary research · 2022Article
- Study on identification, assay and organoleptic quality of veterinary medicines in Ethiopia.Journal of pharmaceutical policy and practice · 2022Article
- Quality and composition of Albendazole, Mebendazole and Praziquantel available in Burkina Faso, Côte d'Ivoire, Ghana and Tanzania.PLoS neglected tropical diseases · 2021Article
- Benchmarking national action plans on antimicrobial resistance in eight selected LMICs: Focus on the veterinary sector strategies.Journal of global health · 2020Article
- In vitro Comparative Quality Assessment of Different Brands of Furosemide Tablets Marketed in Northwest Ethiopia.Drug design, development and therapy · 2020Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundParasitic diseases are the main challenge of livestock production in the world. They are mainly controlled by the use of anthelmintic drugs. To be effective, the drugs should contain the appropriate amount of active pharmaceutical ingredient (API) and have the required physical characteristics. In this study, qualitative and quantitative assessments were performed to evaluate the quality of different brands of albendazole tablets legally circulating in pharmaceutical markets of Addis Ababa, Ethiopia.
methodsUltraviolet-Visible Spectroscopy (UVS), Fourier Transform Infrared Spectroscopy (FTIR) and High-Performance Liquid Chromatography (HPLC) were used for identification. Quantitative analysis was performed by HPLC. United States Pharmacopeia standard was used as a control to evaluate the identity and content of the API in the samples. A total of 10 batches of albendazole tablets from six different brands were collected and evaluated.
resultsAll brands of albendazole tablets, except one, had acceptable physical characteristics. There was gross contamination in one batch, weight variation in 4 (40%) batches, and absence of package insert in 2 (20%) batches. All three methods of evaluation (UVS, FTIR and HPLC) confirmed that all batches passed the identity test. Quantitative analysis showed that no batch had API above the acceptable limit. However, 30% of batches from three different brands contained lower amount of API per tablet than the acceptable limit.
conclusionsAll batches of albendazole circulating in the market in Addis Ababa did not fulfil either physical or chemical quality standards. The most important finding of this research was the presence of drugs with lower level of API than the acceptable limit. This can lead to treatment failure and favour the emergence of parasites that are resistant to drugs. Therefore, there should be a thorough evaluation of drugs before approval. The study also revealed the importance of occasional assessment of drugs circulating even in the legal market.
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