ArticleBMC oral health2019
The effect of missing teeth on dementia in older people: a nationwide population-based cohort study in South Korea.
Article in BMC oral health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Dentition-Cognition Relationship in Aging Populations: A Meta-Analysis of Longitudinal Data.Journal of oral rehabilitation · 2026Pooled it
- Tooth loss and the risk of cognitive decline and dementia: A meta-analysis of cohort studies.Frontiers in neurology · 2023Pooled it
- Periodontal health, cognitive decline, and dementia: A systematic review and meta-analysis of longitudinal studies.Journal of the American Geriatrics Society · 2022Pooled it
- Oral Health Status and Need for Oral Care in an Aging Population: A Systematic Review.International journal of environmental research and public health · 2019Pooled it
- Alzheimer's Disease and Oral Health from Clinical Challenges to Interdisciplinary Care: A Narrative Review.Journal of clinical medicine · 2025Review
- Association Between Cardiovascular Disease and Complete Edentulism in U.S. Adults.Journal of clinical medicine · 2025Article
- Loss of dental pulp potentially increased the risk of Alzheimer's dementia.Journal of dental sciences · 2025Article
- Oral Health Literacy and Determinants among an Elderly Community in Portugal.International journal of environmental research and public health · 2024Observational
- Association Between Subjective Masticatory Function and Mild Cognitive Impairment in Older Adults.International dental journal · 2024Article
- The association between oral health and mild cognitive impairment in community-dwelling older adults.Frontiers in public health · 2024Article
- Projecting trends in the disease burden of adult edentulism in China between 2020 and 2030: a systematic study based on the global burden of disease.Frontiers in public health · 2024Article
- Age-group-specific association of oral health and systemic health on cognitive function: a cross-sectional study of Korean elders.BMC oral health · 2023Article
- Poor Oral Health Linked with Higher Risk of Alzheimer's Disease.Brain sciences · 2023Article
- Prediction Model Development and Validation of 12-Year Incident Edentulism of Older Adults in the United States.JDR clinical and translational research · 2023Article
- Edentulism Predicts Cognitive Decline in the US Health and Retirement Cohort Study.Journal of dental research · 2023Article
- Antibodies against Periodontal Microorganisms and Cognition in Older Adults.JDR clinical and translational research · 2023Article
- A time-dependent subdistribution hazard model for major dental treatment events in cancer patients: a nationwide cohort study.BMC oral health · 2023Article
- The role of microbiome-host interactions in the development of Alzheimer´s disease.Frontiers in cellular and infection microbiology · 2023Review
- Association of Tooth Loss with Alzheimer's Disease Tau Pathologies Assessed by Positron Emission Tomography.Journal of Alzheimer's disease : JAD · 2023Article
- Association between dentition and frailty and cognitive function in community-dwelling older adults.BMC geriatrics · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo determine the effect of missing teeth on the risk of dementia onset among individuals who received tooth extractions and those who did not, based on the number of missing teeth.
methodsWe selected individuals who had not been diagnosed or treated for dementia between 2002 to 2011 from the National Health Insurance Service-Elderly Cohort Database (NHIS-ECD). We divided participants into two cohorts, a tooth extraction and non-extraction cohort, based on tooth loss from 2002 to 2011. After propensity score matching, there were 104,903 individuals in each cohort, and we included a total of 209,806 individuals in this study. Each cohort was grouped by sex, age, residential area, health insurance eligibility, income level, history of dental caries, history of periodontal treatment, and number of extracted teeth. We analyzed the relationship between dementia onset and these variables using logistic regression analysis.
resultsIndividuals with tooth loss had a higher risk for dementia than those without tooth loss (odds ratio [OR] = 1.18; 95% confidence interval [CI]: 1.146-1.215). Regarding the incidence of dementia, the OR increased as the number of missing teeth and age increased, and the OR was higher for women (OR = 1.33; 95% CI: 1.286-1.367) than for men, and this difference was statistically significant (P < 0.01). The incidence of dementia decreased with periodontal treatment (OR = 0.96; 95% CI: 0.932-0.992) and increased with dental caries (OR = 1.07; 95% CI: 1.035-1.101).
conclusionsThese results suggest that it is important to delay tooth loss and preserve the stable remaining teeth to help prevent dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.