Evidence map›Paper›PMID 31023291›Full record

ArticleBMC pediatrics2019

Follow-up study of neurodevelopment in 2-year-old infants who had suffered from neonatal hypoglycemia.

Lin-Xia Qiao, Jian Wang, Ju-Hua Yan, Su-Xiang Xu, Hua Wang, Wen-Ying Zhu, Hai-Yan Zhang, Jie Li, Xing Feng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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  15. Cerebral Effects of Neonatal Dysglycemia.Clinics in perinatology · 2022
    Review
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  18. Decreasing early hypoglycemia frequency in at-risk newborns after implementing a new hypoglycemia screening algorithm.Journal of perinatology : official journal of the California Perinatal Association · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Lin-Xia QiaoDepartment of Neonatology, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215025, Jiangsu, China.
Jian WangDepartment of Children's Healthcare, Kunshan Maternal and Child Health Hospital, Kunshan, 215300, Jiangsu, China.
Ju-Hua YanDepartment of Children's Healthcare, Kunshan Maternal and Child Health Hospital, Kunshan, 215300, Jiangsu, China.
Su-Xiang XuDepartment of Children's Healthcare, Kunshan Maternal and Child Health Hospital, Kunshan, 215300, Jiangsu, China.
Hua WangDepartment of Pediatrics, The First People's Hospital, Jiangsu University, Kunshan, 215300, Jiangsu, China.
Wen-Ying ZhuDepartment of Pediatrics, The First People's Hospital, Jiangsu University, Kunshan, 215300, Jiangsu, China.
Hai-Yan ZhangDepartment of Pediatrics, The First People's Hospital, Jiangsu University, Kunshan, 215300, Jiangsu, China.
Jie LiDepartment of Pediatrics, The First People's Hospital, Jiangsu University, Kunshan, 215300, Jiangsu, China.
Xing FengDepartment of Neonatology, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215025, Jiangsu, China. xing_feng66@hotmail.com.
First People's Hospital of Kunshan · CNYunnan Maternal and Child Health · CNJiangsu University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeonatal hypoglycemia is tightly related to adverse neurodevelopmental and brain injury outcomes.

methodsA total of 195 infants who were born from diabetic mothers with a low blood glucose level (< 2.6 mM) within 0.5 h after birth were enrolled in this prospective cohort study. Of these, 157 infants who had neonatal hypoglycemia (group A) were followed up, and this group was further divided into A1 [blood glucose concentration (BGC) < 2.6 mM at < 2 h after birth], A2 (BGC < 2.6 mM at 2-24 h after birth), and A3 (BGC < 2.6 mM at > 24 h after birth). A total of 144 infants whose mothers had no high risk for gestational diabetes mellitus were followed up as the control group during the same period. The neurodevelopment of the infants was evaluated by the Gesell scoring method.

resultsThe adaptability in the A2 and A3 subgroups was significantly lower than that in the control group (73.9 ± 6.6 vs. 87.9 ± 11.2; 71.5 ± 8.9 vs. 87.9 ± 11.2, respectively). There were significantly more mothers who used insulin during the perinatal period in A3 than in A1 and A2 (31% vs. 2%; 31% vs. 7.9%, respectively). The mothers of babies in subgroups A2 and A3 gained more weight than those of the control group (15.3 ± 1.9 kg vs. 11.1 ± 2.2 kg; 14.8 ± 2.6 kg vs. 11.1 ± 2.2 kg, respectively).

conclusionsLong and repeated neonatal hypoglycemia caused poor adaptability. The babies of mothers who used insulin or had a high weight gain during pregnancy were associated with severe or persistent neonatal hypoglycemia.

Indexed as

Adaptation, PsychologicalAdultAge FactorsBlood GlucoseCase-Control StudiesChild, PreschoolChinaDiabetes, GestationalFemaleFollow-Up StudiesHumansHypoglycemiaIncidenceInfantInfant, NewbornInfant, Newborn, DiseasesBlood GlucoseFollow-upHypoglycemiaNeonateNeurodevelopment

Identifiers

PMID31023291
PMCPMC6485053
OpenAlexW2947170007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.