SynthesisBMC surgery2019
Laparoscopic appendectomy versus open appendectomy for suspected appendicitis during pregnancy: a systematic review and updated meta-analysis.
Synthesis in BMC surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05430633 (Laparoscopic Versus Open Appendectomy in Pregnancy. 10 Year Results of Estonian Population.), which is not on this map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Laparoscopic Versus Open Appendectomy in Pregnancy. 10 Year Results of Estonian Population.
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Antibiotic versus surgery in the treatment of acute appendicitis in the pregnant population: A systematic review and meta-analysis.F1000Research · 2023Pooled it
- Updated Evaluation of Laparoscopic vs. Open Appendicectomy During Pregnancy: A Systematic Review and Meta-Analysis.Frontiers in surgery · 2021Pooled it
- Acute Appendicitis in Childhood and Adulthood.Deutsches Arzteblatt international · 2020Pooled it
- Discordant outcomes of laparoscopic versus open appendectomy for suspected appendicitis during pregnancy in published meta-analyses: an overview of systematic reviews.Surgical endoscopy · 2020Pooled it
- Can clinical scoring systems overcome the limitations of diagnostic methods for acute appendicitis in pregnancy?Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Assessment of Acute Appendicitis in Pregnant Women: A Systematic Review of Current Evidence.Cureus · 2026Review
- Appendectomy During Pregnancy and the Risk of Preterm Birth: A Systematic Review of Contemporary Clinical Studies.Journal of clinical medicine · 2026Review
- Efficacy of endoscopic retrograde appendicitis therapy in children with suppurative vs. simple appendicitis: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Gestational Age-Adapted Laparoscopic Appendectomy for Acute Appendicitis during Pregnancy: Intraoperative Strategies and Outcomes from a Single-Center Case Series.Surgical case reports · 2026Article
- Acute appendicitis during pregnancy: a case-control study.Frontiers in surgery · 2026Article
- Minimally Invasive Surgical Techniques in the Treatment of Appendicitis: A Narrative Review.Cureus · 2025Review
- A complex case of acute abdomen.International journal of emergency medicine · 2025Article
- Appendectomy for suspected appendicitis during pregnancy- a retrospective comparative study of 99 pregnant and 1796 non-pregnant women.Langenbeck's archives of surgery · 2024Article
- Review
- Is non-operative treatment of acute appendicitis possible: A narrative review.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2024Review
- Is Appendectomy During Late Stages of Pregnancy Associated with an Increased Cesarean Delivery Rate? - a Retrospective Analysis of One Center During 10 Years.Geburtshilfe und Frauenheilkunde · 2024Article
- Comparative Analysis of Laparoscopic Versus Open Procedures in Specific General Surgical Interventions.Cureus · 2024Review
- Current approaches to treating acute appendicitis in the third trimester.Trauma surgery & acute care open · 2024Article
- The Association of Polish Surgeons (APS) clinical guidelines for the use of laparoscopy in the management of abdominal emergencies. Part II.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2023Article
- Clinical Characteristics of Acute Appendicitis in Pregnancy: 10-Year Experience at a Single Institution in South Korea.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, laparoscopic appendectomies (LAs) have been widely performed instead of open appendectomies (OAs) during pregnancy. However, concerns about the safety of LA during pregnancy remain. This systematic review and meta-analysis aimed to evaluate the current evidence relating to the safety of LA versus OA for suspected appendicitis during pregnancy.
methodsComprehensive literature searches were conducted using the PubMed, EMBASE, and Cochrane Library databases to identify articles describing LA versus OA in pregnancy, without restrictions regarding the publication date. The primary endpoints were fetal loss and preterm delivery.
resultsAfter screening 801 studies, 22 comparative cohort studies were included in the analysis, which involved 4694 women, of whom 905 underwent LAs and 3789 underwent OAs. Fetal loss was significantly higher among those who underwent LAs compared with those who underwent OAs, and the pooled odds ratio (OR) was 1.72 (95% confidence interval [CI]: 1.22-2.42) without heterogeneity. The sensitivity analysis showed that the effect size was influenced by one of the studies, because its removal resulted in there being no significant difference between LA and OA with respect to the risk of fetal loss (OR 1.163, 95% CI: 0.68-1.99; P = 0.581). A significant difference was not evident between LA and OA with respect to preterm delivery (OR 0.76, 95% CI: 0.51-1.15), a result that did not change following the sensitivity analysis. The patients who underwent LA had shorter hospital stays (mean difference - 1.01, 95% CI: -1.61--0.41) and a lower wound infection risk (OR 0.40, 95% CI: 0.21-0.76) compared with those who underwent OA.
conclusionIt is not reasonable to conclude that LA in pregnant women might be associated with a greater risk of fetal loss. The difference between LA and OA with respect to preterm delivery was not significant.
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Registered trials
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