ArticleBMC pregnancy and childbirth2019
Age at menarche and risk of gestational diabetes mellitus: a population-based study in Xiamen, China.
Article in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 21 citations in OpenAlex.
- Age at menarche and adverse pregnancy and perinatal outcomes: triangulating evidence from multivariable and Mendelian randomization analyses.International journal of epidemiology · 2026Article
- Age at menarche and age-adjusted anti-Müllerian hormone level among women of childbearing age in China.Journal of ovarian research · 2026Article
- Article
- Early-life menstrual characteristics and gestational diabetes in a large US cohort.Paediatric and perinatal epidemiology · 2024Article
- Early age at menarche and the risk of gestational diabetes mellitus: a cohort study.Endocrine · 2024Article
- Early age at menarche is associated with an increased risk of preeclampsia and adverse neonatal outcomes: a 6‑year retrospective study.Archives of gynecology and obstetrics · 2024Article
- Growth in Infancy and Childhood and Age at Menarche in Five Low- or Middle-Income Countries: Consortium of Health Orientated Research in Transitional Societies (COHORTS).The Journal of nutrition · 2023Article
- Development and validation of risk prediction models for large for gestational age infants using logistic regression and two machine learning algorithms.Journal of diabetes · 2023Article
- Development and Validation of Risk Prediction Models for Gestational Diabetes Mellitus Using Four Different Methods.Metabolites · 2022Article
- Association between Age at Menarche and Metabolic Syndrome in Southwest Iran: A Population-Based Case-Control Study.Journal of research in health sciences · 2022Article
- A cross-sectional study to develop an early risk prediction tool for gestational diabetes mellitus for antenatal women diagnosed with this condition based on their characteristics and past obstetric history.Journal of family medicine and primary care · 2022Article
- Steroids, steroid associated substances and gestational diabetes mellitus.Physiological research · 2021Review
- Risk Factors Screening for Gestational Diabetes Mellitus Heterogeneity in Chinese Pregnant Women: A Case-Control Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
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11 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been reported that earlier age at menarche is associated with a higher risk for type 2 diabetes mellitus. However, the relationship between age at menarche and gestational diabetes mellitus is inconsistent across studies. We hypothesized that an earlier age at menarche would predict the gestational diabetes mellitus risk.
methodsThis was a population-based, retrospective cohort study of 70,041 women aged 18 to 53 years old, conducted between 2011 and 2018. The subjects were recruited from the Medical Birth Registry in Xiamen, China. Age at menarche was categorized as 8-12, 13, 14, 15, 16-19 years old. Logistic regression analysis and spline analysis was used to assess the risk of the menarche age group for gestational diabetes mellitus. Linear regression analysis was performed to evaluate independent associations between age at menarche and fasting plasma glucose and blood glucose 1 hour and 2 hours after a 75-g of glucose load between 24 and 28 weeks' gestation.
resultsThe overall prevalence of GDM was 17.6%. After adjustment for family history of diabetes, earlier age at menarche (8-12, and 13 years old) was associated with increased odds for GDM (OR, 1.08; 95% CI, 1.02-1.15, and OR, 1.07; 95% CI, 1.03-1.14, respectively) compared with average age at menarche (14 years old). With further adjustment for pre-pregnancy body mass index, blood pressure, educational level, age at delivery, and hepatitis B surface antigen status, this association was attenuated (OR, 0.93, and OR, 1.02, respectively). Multivariable-adjusted spline regression models showed a linear dose-response association between age at menarche and GDM (P for nonlinearity, 0.203; P for linearity, 0.006). On linear regression analysis, earlier age at menarche was significantly associated with increased blood glucose one and 2 hours after a glucose load but not with the fasting plasma glucose.
conclusionsAs expected, early age at menarche was found to be associated with an increased risk of gestational diabetes mellitus. However, this association may be mediated by potential confounding factors other than age. An additional finding was that earlier menarche was significantly related with elevated pregnancy glucose concentrations after a glucose load.
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