Evidence map›Paper›PMID 31023072›Full record

ReviewBiological research for nursing2019

Symptom Science: Advocating for Inclusion of Functional Genetic Polymorphisms.

Mitchell R Knisely, Megan Maserati, Lacey W Heinsberg, Lisa L Shah, Hongjin Li, Yehui Zhu, Yumi Ma, Letitia Y Graves, John D Merriman, Yvette P Conley

Abstract readReview
In one paragraph

Review in Biological research for nursing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Self-report of symptom cluster experiences in cancer patient-caregiver dyads.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  3. Evaluating Associations between Average Pain Intensity and Genetic Variation in People with Sickle Cell Disease: An Exploratory Study.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2023
    Article
  4. Article
  5. Genes · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mitchell R Knisely1 School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Megan Maserati1 School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Lacey W Heinsberg1 School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-7690-5485
Lisa L Shah1 School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Hongjin Li1 School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Yehui Zhu1 School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Yumi Ma1 School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Letitia Y Graves1 School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
John D Merriman2 New York University Rory Meyers College of Nursing, New York, NY, USA.ORCID 0000-0002-7113-5389
Yvette P Conley1 School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Targeting Research and Academic Training of Nurses in GenomicsT32NR009759 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONLEY, YVETTE P · 2006 to 2025
$4.5M
Mindfulness-Based Stress Reduction to Improve Cognitive Function During Aromatase Inhibitor TherapyR00NR015473 · NINR · NEW YORK UNIVERSITY · PI MERRIMAN, JOHN D. · 2017 to 2019
$731k
Brain Biomarkers of Cognitive and Mood Changes Related to Aromatase Inhibitor UseK99NR015473 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERRIMAN, JOHN D. · 2015 to 2016
$190k
Multi-omics of the Iron Homeostasis Pathway in Patient Outcomes Following aSAHF31NR017311 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HEINSBERG, LACEY W · 2017 to 2019
$115k
Musculoskeletal Pain Among Breast Cancer Survivors: Through Bio-behavioral and Imaging LensesF99CA234782 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHU, YEHUI · 2018 to 2019
$91k
NINR NIH HHS K99 NR015473NINR NIH HHS T32 NR009759
6 · The paper itself

Abstract

Incorporating biologically based data into symptom science research can contribute substantially to understanding commonly experienced symptoms across chronic conditions. The purpose of this literature review was to identify functional polymorphisms associated with common symptoms (i.e., pain, sleep disturbance, fatigue, affective and cognitive symptoms) with the goal of identifying a parsimonious list of functional genetic polymorphisms with evidence to advocate for their inclusion in symptom science research. PubMed was searched to identify genes and functional polymorphisms associated with symptoms across chronic conditions, revealing eight functional genetic polymorphisms in seven different genes that showed evidence of association with at least three or more symptoms and/or symptom clusters:

Indexed as

GenotypePolymorphism, GeneticBiological PhenomenaBiomarkersFatigueHumansPainSleep Wake DisordersSyndromeBiomarkersbiomarkerfunctional genetic polymorphismsymptom science

Identifiers

PMID31023072
PMCPMC6700869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.