Evidence map›Paper›PMID 31023000›Full record

ArticleInternational journal of stem cells2019

Hybrid Nanofiber Scaffold-Based Direct Conversion of Neural Precursor Cells/Dopamine Neurons.

Mi-Sun Lim, Seung Hwan Ko, Min Sung Kim, Byungjun Lee, Ho-Sup Jung, Keesung Kim, Chang-Hwan Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mi-Sun LimResearch and Development Center, Jeil Pharmaceutical Company, Yongin, Korea.
Seung Hwan KoGraduate School of Biomedical Science & Engineering, Hanyang University, Seoul, Korea.
Min Sung KimSchool of Mechanical & Aerospace Engineering, Seoul National University, Seoul, Korea.
Byungjun LeeSchool of Mechanical & Aerospace Engineering, Seoul National University, Seoul, Korea.
Ho-Sup JungCenter for Food and Bioconvergence, Department of Food Science and Biotechnology, Seoul National University, Seoul, Korea.
Keesung KimResearch Institute of Advanced Materials, Seoul National University, Seoul, Korea.
Chang-Hwan ParkGraduate School of Biomedical Science & Engineering, Hanyang University, Seoul, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The concept of cellular reprogramming was developed to generate induced neural precursor cells (iNPCs)/dopaminergic (iDA) neurons using diverse approaches. Here, we investigated the effects of various nanoscale scaffolds (fiber, dot, and line) on iNPC/iDA differentiation by direct reprogramming. The generation and maturation of iDA neurons (microtubule-associated protein 2-positive and tyrosine hydroxylase-positive) and iNPCs (NESTIN-positive and SOX2-positive) increased on fiber and dot scaffolds as compared to that of the flat (control) scaffold. This study demonstrates that nanotopographical environments are suitable for direct differentiation methods and may improve the differentiation efficiency.

Indexed as

Direct conversionHybrid nanofiberiNPCNeural precursor

Identifiers

PMID31023000
PMCPMC6657951

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.